PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28870898-6	2017	Our studies indicated that ATA strongly inactivates and binds in the PTP1B and SHP2 active site, interacting with arginine residue essential for enzyme activity.	Arginine	114-122	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	79-83	
16413071-1	2006	Most classical phosphotyrosyl phosphatases (PTPs), including the Src homology phosphotyrosyl phosphatase 2 (SHP2) possess a Thr or a Ser residue immediately C-terminal to the invariant Arg in the active site consensus motif (H/V-C-X5-R-S/T), also known as the "signature motif".	Arginine	185-188	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	65-106	
16413071-1	2006	Most classical phosphotyrosyl phosphatases (PTPs), including the Src homology phosphotyrosyl phosphatase 2 (SHP2) possess a Thr or a Ser residue immediately C-terminal to the invariant Arg in the active site consensus motif (H/V-C-X5-R-S/T), also known as the "signature motif".	Arginine	185-188	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	108-112	
9485424-4	1998	In the SH2 domains of SHP-2, the highly conserved alphaA2 Arg is replaced by Gly.	Arginine	58-61	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-27	
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	28-33	
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	133-138	
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	133-138	
16702225-4	2006	These studies reveal that binding of a pY peptide to the N-SH2 domain of SHP-2 is greatly enhanced by a large hydrophobic residue (Trp, Tyr, Met, or Phe) at the pY+4 and/or pY+5 positions, whereas binding to SHP-1 N-SH2 domain is enhanced by either hydrophobic or positively charged residues (Arg, Lys, or His) at these positions.	Arginine	293-296	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	73-78	
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Arginine	134-137	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	57-61	
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Arginine	134-137	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	69-73