PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34888656-7	2022	Using a combination of in vitro methylation and cell-based experiments we identified PRMT4 (CARM1) and PRMT6 as major enzymes methylating HTT at specific arginines.	Arginine	154-163	huntingtin	Homo sapiens	138-141	
19204007-7	2009	Using mass spectrometry, we found that the cp-2 fragment is generated by cleavage of huntingtin at position Arg(167).	Arginine	108-111	huntingtin	Homo sapiens	85-95	
19204007-10	2009	These data suggest that cleavage of huntingtin at residue Arg(167) may mediate mutant huntingtin toxicity in Huntington disease.	Arginine	58-61	huntingtin	Homo sapiens	36-46	
19204007-10	2009	These data suggest that cleavage of huntingtin at residue Arg(167) may mediate mutant huntingtin toxicity in Huntington disease.	Arginine	58-61	huntingtin	Homo sapiens	86-96	
34888656-0	2022	Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.	Arginine	62-70	huntingtin	Homo sapiens	15-25	
34888656-11	2022	Thus, arginine methylation pathways that involve specific HTT-modifying PRMT enzymes and modulate HTT biochemical and toxic properties could provide targets for HD-modifying therapies.	Arginine	6-14	huntingtin	Homo sapiens	58-61	
34888656-0	2022	Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.	Arginine	62-70	huntingtin	Homo sapiens	27-30	
34888656-0	2022	Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.	Arginine	62-70	huntingtin	Homo sapiens	91-94	
34888656-11	2022	Thus, arginine methylation pathways that involve specific HTT-modifying PRMT enzymes and modulate HTT biochemical and toxic properties could provide targets for HD-modifying therapies.	Arginine	6-14	huntingtin	Homo sapiens	98-101	
34888656-3	2022	Arginine methylation/dimethylation is an important modification with an emerging role in neurodegeneration, however arginine methylation of HTT remains largely unexplored.	Arginine	116-124	huntingtin	Homo sapiens	140-143	
34888656-4	2022	Here we report nearly two dozen novel arginine methylation/dimethylation sites on the endogenous HTT from human and mouse brain and human cells suggested by mass spectrometry with data-dependent acquisition (DDA).	Arginine	38-46	huntingtin	Homo sapiens	97-100	
25927346-0	2015	PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington"s disease (HD).	Arginine	26-34	huntingtin	Homo sapiens	73-83	
27560450-5	2016	Consistently, the inhibition of the Arg/N-end rule pathway with PCA significantly elevated levels of MAPT and huntingtin aggregates, accompanied by increased numbers of LC3 and SQSTM1 puncta.	Arginine	36-39	huntingtin	Homo sapiens	110-120	
33852844-0	2021	Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.	Arginine	46-54	huntingtin	Homo sapiens	0-10	
33852844-2	2021	To better understand how HTT mediates axonal transport and why this function is disrupted in Huntington"s disease (HD), we study vesicle-associated HTT and find that it is dimethylated at a highly conserved arginine residue (R118) by the protein arginine methyltransferase 6 (PRMT6).	Arginine	207-215	huntingtin	Homo sapiens	148-151	
33852844-6	2021	Arginine methylation thus regulates HTT-mediated vesicular transport along the axon, and increasing HTT methylation could be of therapeutic interest for HD.	Arginine	0-8	huntingtin	Homo sapiens	36-39	
25927346-2	2015	Here, we explored a functional interaction of Htt with protein arginine methyltransferase 5 (PRMT5), an enzyme mediating symmetrical dimethylation of arginine (sDMA) of key cellular proteins, including histones, and spliceosomal Sm proteins.	Arginine	63-71	huntingtin	Homo sapiens	46-49	
25927346-9	2015	These studies revealed a potential new mechanism for disruption of gene expression and RNA processing in HD, involving a loss of normal function of Htt in facilitation of PRMT5, supporting the idea that epigenetic regulation of gene transcription may be involved in HD and highlighting symmetric dimethylation of arginine as potential new therapeutic target.	Arginine	313-321	huntingtin	Homo sapiens	148-151