PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32866611-2	2020	CLK1 belongs to the CLK kinase family that regulates alternative splicing through phosphorylation of serine-arginine rich (SR) proteins.	Arginine	108-116	CDC like kinase 1	Homo sapiens	0-4	
23707382-8	2013	The data establish a new view of SR protein regulation in which SRPK1 and CLK1 partition activities based on Ser-Pro versus Arg-Ser placement rather than on N- and C-terminal preferences along the RS domain.	Arginine	124-127	CDC like kinase 1	Homo sapiens	74-78	
24568585-5	2014	CLK1 plays an important role in the regulation of RNA splicing through phosphorylation of members of the serine and arginine-rich (SR) family of splicing factors.	Arginine	116-124	CDC like kinase 1	Homo sapiens	0-4	
11418604-7	2001	Furthermore, hPRP4 interacted directly with Clk1 on its COOH terminus, and the arginine/serine-rich domain of hPRP4 was phosphorylated by Clk1 in vitro.	Arginine	79-87	CDC like kinase 1	Homo sapiens	44-48	
23707382-5	2013	While SRPK1 rapidly phosphorylates N-terminal serines, SRPK1 and CLK1 display similar activities toward Arg-Ser repeats in the C-terminus, suggesting that these kinases may not separate function in a strict linear manner along the RS domain.	Arginine	104-107	CDC like kinase 1	Homo sapiens	65-69	
23707382-6	2013	CLK1 induces a unique gel shift in SRSF1 that is not the result of enhanced Arg-Ser phosphorylation but rather is the direct result of the phosphorylation of several Ser-Pro dipeptides.	Arginine	76-79	CDC like kinase 1	Homo sapiens	0-4	
21433360-5	2010	The Clk family is known to alter the actions of the spliceosome by phosphorylating the serine-arginine rich (SR) proteins that are critical elements of spliceosome assembly.	Arginine	94-102	CDC like kinase 1	Homo sapiens	4-7	
11418604-7	2001	Furthermore, hPRP4 interacted directly with Clk1 on its COOH terminus, and the arginine/serine-rich domain of hPRP4 was phosphorylated by Clk1 in vitro.	Arginine	79-87	CDC like kinase 1	Homo sapiens	138-142	
8798720-0	1996	SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.	Arginine	83-91	CDC like kinase 1	Homo sapiens	10-17	
8798720-6	1996	In vitro, the Clk/Sty kinase phosphorylated Ser-Arg, Ser-Lys, or Ser-Pro sites, whereas SRPK1 had a strong preference for Ser-Arg sites.	Arginine	48-51	CDC like kinase 1	Homo sapiens	14-17	
8798720-6	1996	In vitro, the Clk/Sty kinase phosphorylated Ser-Arg, Ser-Lys, or Ser-Pro sites, whereas SRPK1 had a strong preference for Ser-Arg sites.	Arginine	126-129	CDC like kinase 1	Homo sapiens	14-17	
8617202-2	1996	In a yeast two-hybrid screen, the Clk/Sty kinase specifically interacted with RNA binding proteins, particularly members of the serine/arginine-rich (SR) family of splicing factors.	Arginine	135-143	CDC like kinase 1	Homo sapiens	34-37	
8617202-3	1996	Clk/Sty itself has an serine/arginine-rich non-catalytic N-terminal region which is important for its association with SR splicing factors.	Arginine	29-37	CDC like kinase 1	Homo sapiens	0-3	
8617202-4	1996	In vitro, Clk/Sty efficiently phosphorylated the SR family member ASF/SF2 on serine residues located within its serine/arginine-rich region (the RS domain).	Arginine	119-127	CDC like kinase 1	Homo sapiens	10-13	
34184765-2	2021	nSBs repress splicing of hundreds of introns during thermal stress recovery, which are partly regulated by CLK1 kinase phosphorylation of temperature-dependent Ser/Arg-rich splicing factors (SRSFs).	Arginine	164-167	CDC like kinase 1	Homo sapiens	107-111