PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26659906-1 2016 We describe the 3D supramolecular structure of Fmoc-RGDS fibrils, where Fmoc and RGDS refer to the hydrophobic N-(fluorenyl-9-methoxycarbonyl) group and the hydrophilic Arg-Gly-Asp-Ser peptide sequence, respectively. Arginine 169-172 ral guanine nucleotide dissociation stimulator Homo sapiens 52-56 28803402-6 2018 The inhibition of actin dynamics by treatment with latrunculin B or jasplakinolide and the disruption of the adhesion between the PM and the CW by treatment with RGDS peptide (Arg-Gly-Asp-Ser) enhanced guard cell plasmolysis. Arginine 176-179 ral guanine nucleotide dissociation stimulator Homo sapiens 162-166 28416846-2 2017 The Arg-Gly-Asp-Ser sequence (RGDS) was confirmed of affecting cell adhesion. Arginine 4-7 ral guanine nucleotide dissociation stimulator Homo sapiens 30-34 27762493-4 2017 Here, we have addressed this limitation through the development of a controlled release system, matrix-metalloproteinase (MMP)-sensitive and arg-gly-asp-ser (RGDS) peptide functionalized poly (ethylene-glycol) (PEG) particles which are synthesized via visible-light-induced water-in-water emulsion polymerization. Arginine 141-144 ral guanine nucleotide dissociation stimulator Homo sapiens 158-162 26659906-1 2016 We describe the 3D supramolecular structure of Fmoc-RGDS fibrils, where Fmoc and RGDS refer to the hydrophobic N-(fluorenyl-9-methoxycarbonyl) group and the hydrophilic Arg-Gly-Asp-Ser peptide sequence, respectively. Arginine 169-172 ral guanine nucleotide dissociation stimulator Homo sapiens 81-85 24124363-3 2013 In this study, we explore the preparation and characterization of gadolinium (Gd)-loaded poly (lactic-co-glycolic acid) (PLGA) particles surface modified with the Arg-Gly-Asp-Ser (RGDS) peptide for the detection of thrombus. Arginine 163-166 ral guanine nucleotide dissociation stimulator Homo sapiens 180-184 25680633-2 2015 To improve cell attachment, arginine-glycine-aspartic acid-serine (RGDS) peptides were covalently grafted to chitosan films, through the widely used coupling agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC-HCl) and N-hydroxysuccinimide (NHS), via the carboxylic acid function of the RGDS molecule. Arginine 28-36 ral guanine nucleotide dissociation stimulator Homo sapiens 67-71 25680633-2 2015 To improve cell attachment, arginine-glycine-aspartic acid-serine (RGDS) peptides were covalently grafted to chitosan films, through the widely used coupling agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC-HCl) and N-hydroxysuccinimide (NHS), via the carboxylic acid function of the RGDS molecule. Arginine 28-36 ral guanine nucleotide dissociation stimulator Homo sapiens 293-297 22961935-3 2013 Herein, we prepared RGDS peptide photocaged either on the Arg-Gly backbone amide nitrogen atom (R[-]GDS) or Asp side chain carboxyl (RG[D]S). Arginine 58-61 ral guanine nucleotide dissociation stimulator Homo sapiens 20-24 22242898-5 2012 HepG2 cells were easily immobilized on the arginine-glycine-aspartic acid-serine (RGDS)-multiwalled carbon nanotubes (RGDS-MWCNTs) nanocomposite by the specific combination of RGD domains with integrin receptors on the cell surface. Arginine 43-51 ral guanine nucleotide dissociation stimulator Homo sapiens 82-86 22242898-5 2012 HepG2 cells were easily immobilized on the arginine-glycine-aspartic acid-serine (RGDS)-multiwalled carbon nanotubes (RGDS-MWCNTs) nanocomposite by the specific combination of RGD domains with integrin receptors on the cell surface. Arginine 43-51 ral guanine nucleotide dissociation stimulator Homo sapiens 118-122 22619531-5 2012 PEG hydrogel-coated MIONPs were further functionalized with the fibronectin-derived arginine-glycine-aspartic acid-serine (RGDS) sequence, in order to achieve a biofunctional PEG hydrogel layer around the nanoparticles. Arginine 84-92 ral guanine nucleotide dissociation stimulator Homo sapiens 123-127 16153125-7 2005 To encourage cell adhesion, PUs were surface-modified with radio frequency glow discharge followed by coupling of Arg-Gly-Asp-Ser (RGDS). Arginine 114-117 ral guanine nucleotide dissociation stimulator Homo sapiens 131-135 20213214-2 2010 Here we have developed a novel strategy to pattern cells using a hyaluronic acid hydrogel material and photocaged RGDS (Arg-Gly-Asp-Ser) peptides. Arginine 120-123 ral guanine nucleotide dissociation stimulator Homo sapiens 114-118 19528482-4 2009 As expected, these enhancements were markedly suppressed with the addition of anti-alphavbeta3 antibody or arginine-glycine-aspartic acid serine (RGDS) peptide to the medium. Arginine 107-115 ral guanine nucleotide dissociation stimulator Homo sapiens 146-150 18413142-2 2008 Using hexameric peptide library of FN-III(8-11) scan, we identified the ALNGR (Ala-Leu-Asn-Gly-Arg) peptide that induced cell adhesion as well as RGDS (Arg-Gly-Asp-Ser) peptide. Arginine 95-98 ral guanine nucleotide dissociation stimulator Homo sapiens 146-150 16418218-8 2006 Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide. Arginine 183-186 ral guanine nucleotide dissociation stimulator Homo sapiens 200-204 20643479-2 2010 Here, we focused on integrin-mediated cell-scaffold adhesion and prepared cell adhesive fibroin in which a tandem repeat of the Arg-Gly-Asp-Ser (RGDS) sequence was genetically interfused in the fibroin light chain (L-chain) (L-RGDSx2 fibroin). Arginine 128-131 ral guanine nucleotide dissociation stimulator Homo sapiens 145-149 18803481-5 2009 To manipulate EC adhesion, migration, and tubulogenesis, the surface of PEGDA hydrogels was micropatterned with a cell adhesive ligand, Arg-Gly-Asp-Ser (RGDS), in desired concentrations and geometries. Arginine 136-139 ral guanine nucleotide dissociation stimulator Homo sapiens 153-157 15004000-7 2004 treating cells cultured on fibronectin with soluble Arg-Gly-Asp-Ser (RGDS) peptide to specifically block integrin-fibronectin interactions. Arginine 52-55 ral guanine nucleotide dissociation stimulator Homo sapiens 69-73 15684686-5 2004 The current experiments analyze the interactions of isolated human neutrophils with PEG hydrogels modified with Arg-Gly-Asp-Ser (RGDS), a known ligand for some beta(1) and beta(3) integrins, and Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Thr-Ile-Gly-Gly (TMKIIPFNRLTIGG), a ligand for Mac-1, a beta(2) integrin. Arginine 112-115 ral guanine nucleotide dissociation stimulator Homo sapiens 129-133 11418470-11 2001 RGDS (Arg-Gly-Asp-Ser) or antibodies to alpha5beta1 or alphaIIbbeta3 integrins caused a partial decrease in LPA-induced deposition of FITC-FN. Arginine 6-9 ral guanine nucleotide dissociation stimulator Homo sapiens 0-4 15003013-1 2004 In this study, specific interactions between immobilized RGDS (Arg-Gly-Asp-Ser) cell adhesion peptides and cell integrin receptors located on cell membranes are controlled in vitro using stimuli-responsive polymer surface chemistry. Arginine 63-66 ral guanine nucleotide dissociation stimulator Homo sapiens 57-61 12469900-7 2002 Furthermore, the Arg-Gly-Asp-Ser(RGDS)-peptide effectively inhibited collagen-triggered aggregation and CL, and the subsequent enhancement of the fMet-Leu-Phe-induced responses. Arginine 17-20 ral guanine nucleotide dissociation stimulator Homo sapiens 33-37 12115475-5 2002 To encourage cell adhesion, PEUUs were surface modified with radio-frequency glow discharge followed by coupling of Arg-Gly-Asp-Ser (RGDS). Arginine 116-119 ral guanine nucleotide dissociation stimulator Homo sapiens 133-137 8598221-1 1996 The hematopoietic cell recognition sites of human fibronectin (FN) are the Arg-Gly-Asp-Ser (RGDS) sequence recognized by widely distributed integrin receptor alpha 5 beta 1 and the type III connecting segment (III CS) containing two cell-binding sites, designated CS1 and CS5, that are recognized by the alpha 4 beta 1 receptor. Arginine 75-78 ral guanine nucleotide dissociation stimulator Homo sapiens 92-96 11312916-2 2001 The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif. Arginine 67-70 ral guanine nucleotide dissociation stimulator Homo sapiens 84-88 9834112-8 1998 Both the phagocytosis and production of the cytokines were suppressed by either phospho-L-serine or RGDS (Arg-Gly-Asp-Ser), but not by RGES (Arg-Gly-Glu-Ser). Arginine 106-109 ral guanine nucleotide dissociation stimulator Homo sapiens 100-104 7629143-8 1995 The adhesive motif RGDS (Arg-Gly-Asp-Ser) and an epidermal growth factor-like domain were identified. Arginine 25-28 ral guanine nucleotide dissociation stimulator Homo sapiens 19-23 8624397-1 1996 This in vitro study was an investigation of osteoblast functions on glass substrates modified with the bioactive peptide Arg-Gly-Asp-Ser (RGDS) in the absence and presence of recombinant human Osteogenic Protein-1 (OP-1); control substrates were plain glass, glass modified with amine groups, and glass modified with the non-adhesive peptide Arg-Asp-Gly-Ser. Arginine 121-124 ral guanine nucleotide dissociation stimulator Homo sapiens 138-142 8028175-6 1994 I also describe our new protein engineering technique for creation of artificial cell adhesive proteins by grafting the Arg-Gly-Asp Ser (RGDS) cell recognition signal, which was identified first in fibronectin and later in various plasma and extracellular matrix proteins. Arginine 120-123 ral guanine nucleotide dissociation stimulator Homo sapiens 137-141 21043620-4 1995 Thrombin-stimulated platelets but not non-stimulated platelets adhered to the SCSb-9coated surface, and platelet adherence was inhibited in a dose-dependent manner by the tetrapeptide RGDS (Arg-Gly-Asp-Ser). Arginine 190-193 ral guanine nucleotide dissociation stimulator Homo sapiens 184-188 7948575-1 1994 A cell adhesive peptide, Arg-Gly-Asp-Ser (RGDS), enhances leucocyte response to stimuli when insolubilized or conjugated with proteins. Arginine 25-28 ral guanine nucleotide dissociation stimulator Homo sapiens 42-46 8132607-1 1994 Integrin alpha IIb-beta 3 binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser (RGDS). Arginine 72-75 ral guanine nucleotide dissociation stimulator Homo sapiens 89-93 7925478-3 1993 An increased rate of actin polymerization was found in "aggregating" conditions as compared to "activating" conditions, the latter achieved by either absence of stirring or stirring in the presence of the tetrapeptide Arg-Gly-Asp-Ser (RGDS). Arginine 218-221 ral guanine nucleotide dissociation stimulator Homo sapiens 235-239 8077255-1 1994 The adhesive interaction of cells with extracellular matrix components is essential for a variety of cellular functions, and is frequently mediated by a tetra peptide, Arg-Gly-Asp-Ser (RGDS), located within fibronectin and other proteins. Arginine 168-171 ral guanine nucleotide dissociation stimulator Homo sapiens 185-189 8263031-10 1994 Adding the synthetic peptide, arg-gly-asp-ser (RGDS) to the medium, blocked migration on fibronectin-coated implants but had no effect on implants coated with type IV, suggesting that migration on type IV involves different cell surface receptors than those mediating migration over fibronectin. Arginine 30-33 ral guanine nucleotide dissociation stimulator Homo sapiens 47-51 8325838-3 1993 We demonstrate using flow cytometric methods a central role for the beta 3 integrin glycoprotein (GP) IIb-IIIa complex and its ligand tetrapeptide Arg-Gly-Asp-Ser (RGDS) binding site in platelet vesiculation. Arginine 147-150 ral guanine nucleotide dissociation stimulator Homo sapiens 164-168 1400325-4 1992 Cytoskeletal association and platelet aggregation were inhibited by the peptide Arg-Gly-Asp-Ser (RGDS) (but not by Arg-Gly-Glu-Ser (RGES)), by 10E5 antibody against glycoprotein (Gp) IIb/IIIa, and by EGTA. Arginine 80-83 ral guanine nucleotide dissociation stimulator Homo sapiens 97-101 8454570-2 1993 One of these sequences, Arg-Gly-Asp-Ser (RGDS) tetrapeptide, was shown to be transferred to a truncated form of Staphylococcal IgG-binding protein (hereafter referred to as tSPA) with retention of its cell-adhesive activity [Maeda, T. et al. Arginine 24-27 ral guanine nucleotide dissociation stimulator Homo sapiens 41-45 8373751-1 1993 A tetrapeptide RGDS (Arg-Gly-Asp-Ser), which is one of the active sites of cell adhesive proteins, was synthesized according to the solution method and covalently coupled onto monodisperse microspheres. Arginine 21-24 ral guanine nucleotide dissociation stimulator Homo sapiens 15-19 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Arginine 130-133 ral guanine nucleotide dissociation stimulator Homo sapiens 147-151 1326944-4 1992 Tetrapeptide RGDS (Arg-Gly-Asp-Ser), which blocks the interaction of ligands such as fibrinogen with platelet integrin alpha IIb beta 3 (GPIIb-IIIa), inhibited only the late-phase PtdIns(3,4)P2 accumulation that was associated with added Ca2+. Arginine 19-22 ral guanine nucleotide dissociation stimulator Homo sapiens 13-17 1624955-1 1992 Many adhesive proteins present in extracellular matrices and in blood contain the tetrapeptide sequence -Arg-Gly-Asp-Ser- (or RGDS) at their cell recognition site. Arginine 105-108 ral guanine nucleotide dissociation stimulator Homo sapiens 126-130 1737795-0 1992 Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis. Arginine 30-33 ral guanine nucleotide dissociation stimulator Homo sapiens 47-51 1750929-10 1991 The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin. Arginine 57-60 ral guanine nucleotide dissociation stimulator Homo sapiens 125-129 1659747-9 1991 In the third experiment the RGDS peptide (ARG-GLY-ASP-SER), a blocker of GPIIb/IIIa platelet receptor dose dependently inhibited platelet aggregation by 93 +/- 17%. Arginine 42-45 ral guanine nucleotide dissociation stimulator Homo sapiens 28-32 1797805-1 1991 Materials to enhance cell adhesion were synthesized by surface integration of peptide, Arg-Gly-Asp-Ser(RGDS), which is an active-site sequence of cell-adhesive proteins. Arginine 87-90 ral guanine nucleotide dissociation stimulator Homo sapiens 103-107 1751226-4 1991 Furthermore, incorporation of the well known cell adhesive ligand Arg-Gly-Asp-Ser (RGDS) peptidyl moiety into the above co-polymer resulted, on UV light irradiation, in a three-dimensional hydrophilic gel matrix containing cell adhesive ligands. Arginine 66-69 ral guanine nucleotide dissociation stimulator Homo sapiens 83-87 1750929-10 1991 The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin. Arginine 108-111 ral guanine nucleotide dissociation stimulator Homo sapiens 125-129 2527238-2 1989 Since both ligands bind to it through their respective RGDS (Arg-Gly-Asp-Ser) domains and since both have been cloned, we were able to deduce the amino acid sequence of the binding site from the nucleotide sequence coding for RGDS in both proteins. Arginine 61-64 ral guanine nucleotide dissociation stimulator Homo sapiens 55-59 2597139-4 1989 In stirred platelets, total and specific inhibition of PMA-induced aggregation by a fibrinogen-derived peptide (RGDS, i.e. Arg-Gly-Asp-Ser) promoted maximal increases in membrane-associated PKC in the presence of PMA and completely prevented the loss in cellular activity. Arginine 123-126 ral guanine nucleotide dissociation stimulator Homo sapiens 112-116 2613766-10 1989 Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors. Arginine 67-70 ral guanine nucleotide dissociation stimulator Homo sapiens 84-88 1965949-1 1990 The platelet adhesion on adhesive protein-coated surfaces was significantly reduced by the addition of the synthetic tetrapeptide, RGDS (Arg-Gly-Asp-Ser), which was identified as the common amino acid sequence of adhesive site of adhesive proteins. Arginine 137-140 ral guanine nucleotide dissociation stimulator Homo sapiens 131-135 2527238-2 1989 Since both ligands bind to it through their respective RGDS (Arg-Gly-Asp-Ser) domains and since both have been cloned, we were able to deduce the amino acid sequence of the binding site from the nucleotide sequence coding for RGDS in both proteins. Arginine 61-64 ral guanine nucleotide dissociation stimulator Homo sapiens 226-230 2917185-5 1989 Addition of the peptides Arg-Gly-Asp-Ser (RGDS) and fibrinogen gamma-chain carboxyl-terminal (gamma 397-411) at concentrations sufficient to completely block fibrinogen binding to GP IIb-IIIa had no effect on either C5b-9 induced dense granule secretion or the associated turbidity change. Arginine 25-28 ral guanine nucleotide dissociation stimulator Homo sapiens 42-46 2712830-1 1989 Fibronectin, von Willebrand factor, and fibrinogen each bind to the glycoprotein IIb-IIIa complex on activated platelets via an arg-gly-asp-ser (RGDS) sequence present within the adhesive proteins. Arginine 128-131 ral guanine nucleotide dissociation stimulator Homo sapiens 145-149 2910912-2 1989 One peptide (HHLGGAKQAGDV) corresponds to the carboxyl terminal segment of the fibrinogen gamma-chain (gamma 400-411) and the other (RGDS) contains the amino acid sequence Arg-Gly-Asp (RGD) common to fibronectin, von Willebrand factor, vitronectin and the alpha-chain of fibrinogen. Arginine 172-175 ral guanine nucleotide dissociation stimulator Homo sapiens 133-137 3187957-6 1988 Shear-induced platelet aggregation was inhibited by monoclonal antibody to GPIIb/IIIa (1 microgram/ml) and synthetic peptide, Arg-Gly-Asp-Ser (RGDS) (1 mM). Arginine 126-129 ral guanine nucleotide dissociation stimulator Homo sapiens 143-147 3169039-6 1988 The formation of both neurite classes on either pFN or CTB was completely inhibited by low concentrations of an RGDS (Arg-Gly-Asp-Ser) peptide in the medium of cultures, indicating the significance of pFN"s binding to cell surface integrin or ganglioside GM1"s possible interaction with integrin for mediating the differentiative process. Arginine 118-121 ral guanine nucleotide dissociation stimulator Homo sapiens 112-116 2958484-6 1987 These reagents are (a) a soluble synthetic tetrapeptide Arg-Gly-Asp-Ser (RGDS; Pierschbacher, M. D., and E. Ruoslahti, 1984, Nature (Lond. Arginine 56-59 ral guanine nucleotide dissociation stimulator Homo sapiens 73-77 2956269-4 1987 The RGDS tetrapeptide (arg-gly-asp-ser) from the cell attachment domain of fibronectin can specifically block attachment and outgrowth on both fibronectin- and laminin-coated substrates. Arginine 23-26 ral guanine nucleotide dissociation stimulator Homo sapiens 4-8 3025221-8 1986 The tetrapeptide sequence Arg-Glu-Asp-Val (REDV), which is somewhat related to RGDS, was present in this peptide in a highly hydrophilic region of the type III connecting segment. Arginine 26-29 ral guanine nucleotide dissociation stimulator Homo sapiens 79-83 3009364-3 1986 Homology searches in protein data banks revealed the presence of the peptide SDGR in the alpha 2 domain of MHC class I antigens, and a variant of RGDS, Arg-Phe-Asp-Ser (RFDS), was found highly conserved in MHC class I (alpha 1 domain) and class II antigens (beta 1 domain). Arginine 152-155 ral guanine nucleotide dissociation stimulator Homo sapiens 146-150 2460346-1 1988 An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption. Arginine 48-51 ral guanine nucleotide dissociation stimulator Homo sapiens 65-69 2460346-1 1988 An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption. Arginine 48-51 ral guanine nucleotide dissociation stimulator Homo sapiens 93-97 3036276-1 1987 Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain. Arginine 24-27 ral guanine nucleotide dissociation stimulator Homo sapiens 41-45