PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28337703-4 2017 Combination of UMI-77 and TRAIL in glioma cells led to the activation of caspase-8 and Bid, cleavage of caspase-3 and poly-ADP ribose polymerase (PARP), accumulation of tBid in the mitochondria and release of cytochrome c into the cytosol. UMI-77 15-21 poly(ADP-ribose) polymerase 1 Homo sapiens 118-144 28337703-4 2017 Combination of UMI-77 and TRAIL in glioma cells led to the activation of caspase-8 and Bid, cleavage of caspase-3 and poly-ADP ribose polymerase (PARP), accumulation of tBid in the mitochondria and release of cytochrome c into the cytosol. UMI-77 15-21 poly(ADP-ribose) polymerase 1 Homo sapiens 146-150 28659182-7 2017 The selective MCL-1 inhibitor UMI-77 caused dissociation of MCL-1 from the proapoptotic protein BAX and BAK, and enhanced KYSE150 and KYSE510 cells to cisplatin-induced apoptosis accompanied by caspase-3 activation and PARP cleavage. UMI-77 30-36 poly(ADP-ribose) polymerase 1 Homo sapiens 219-223