PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33283357-4 2021 Mechanistically, defactinib dose and time-dependently induced the dissociation of phosphoinositide-3-kinase (PI3K) from FAK, resultantly led to blockade of protein kinase B (AKT) signaling, and the expression of several oncogenes, such as SOX2, MYC, EGFR, MET, MDM2, or TGFBR2, identified by microarray and real-time polymerase chain reaction assay. defactinib 17-27 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 82-107