PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18559975-6 2008 Unlike normal myeloid DCs, adenosine-differentiated DCs have impaired allostimulatory activity and express high levels of angiogenic, pro-inflammatory, immune suppressor, and tolerogenic factors, including VEGF, IL-8, IL-6, IL-10, COX-2, TGF-beta, and IDO. Adenosine 27-36 interleukin 6 Mus musculus 218-222 21799929-5 2011 METHODOLOGY/PRINCIPAL FINDINGS: We tested this hypothesis by neutralizing or genetically removing IL-6 in adenosine deaminase (ADA)-deficient mice that develop adenosine dependent pulmonary inflammation and remodeling. Adenosine 106-115 interleukin 6 Mus musculus 98-102 19194991-2 2009 This study examined the effects of adenosine on interleukin (IL)-6 expression and its related signal pathways in mouse embryonic stem (ES) cells. Adenosine 35-44 interleukin 6 Mus musculus 48-66 19194991-3 2009 In this study, the adenosine analogue 5"-N-ethylcarboxamide (NECA) increased IL-6 protein expression level. Adenosine 19-28 interleukin 6 Mus musculus 77-81 18088370-8 2008 We conclude that adenosine via activation of A2B receptors evokes IL-6 release also in vivo. Adenosine 17-26 interleukin 6 Mus musculus 66-70 15095371-2 2004 It has recently been shown that stimulation of adenosine receptors in glial cells induces the release of neuroprotective substances such as NGF, S-100beta, and interleukin-6 (IL-6). Adenosine 47-56 interleukin 6 Mus musculus 160-173 15843034-7 2005 Importantly, SAMe increased intracellular adenosine levels, and exogenous adenosine supplementation had effects similar to SAMe on TNF, IL-10 and IL-6 production. Adenosine 74-83 interleukin 6 Mus musculus 146-150 15843034-8 2005 3-Deaza-adenosine (DZA), a specific inhibitor of S-adenosylhomocysteine (SAH) hydrolase, blocked the elevation of IL-10 and IL-6 production induced by SAMe, which was rescued by the addition of exogenous adenosine. Adenosine 8-17 interleukin 6 Mus musculus 124-128 15843034-9 2005 Furthermore, the enhancement of LPS-stimulated IL-10 and IL-6 production by both SAMe and adenosine was inhibited by ZM241385, a specific antagonist of the adenosine (A(2)) receptor. Adenosine 90-99 interleukin 6 Mus musculus 57-61 15843034-10 2005 Our results suggest that increased adenosine levels with subsequent binding to the A(2) receptor account, at least in part, for SAMe modulation of IL-10 and IL-6, but not TNF production, from LPS stimulated monocytes. Adenosine 35-44 interleukin 6 Mus musculus 157-161 15095371-2 2004 It has recently been shown that stimulation of adenosine receptors in glial cells induces the release of neuroprotective substances such as NGF, S-100beta, and interleukin-6 (IL-6). Adenosine 47-56 interleukin 6 Mus musculus 175-179 14504137-7 2003 These findings indicate that adenosine can stimulate IL-6 secretion in FS cells via the A2b receptor coupled principally to PLC/PKC and p38 MAPK; such an action may be important in the modulation of inflammatory response processes in the pituitary gland. Adenosine 29-38 interleukin 6 Mus musculus 53-57 14504137-0 2003 Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. Adenosine 0-9 interleukin 6 Mus musculus 18-22 35281058-5 2022 In lipopolysaccharide (LPS)/lipopolysaccharide + adenosine triphosphate (LPS+ATP)-stimulated macrophages, our results showed that HSC remarkably inhibited the secretion of interleukin-6 (IL-6), IL-1beta, and tumor necrosis factor-alpha (TNF-alpha). Adenosine 49-58 interleukin 6 Mus musculus 172-185 14504137-2 2003 We investigated the action of adenosine A2 receptor agonists on IL-6 and VEGF secretion in two murine FS cell lines (TtT/GF and Tpit/F1), and demonstrated a rank order of potency, 5"-N-ethylcarboxamidoadenosine (NECA)>2-p-(2-carboxyethyl)phenethylamino-5"-N-ethylcarboxamidoadenosine>adenosine, suggesting mediation via the A2b receptor. Adenosine 30-39 interleukin 6 Mus musculus 64-68 11960643-0 2002 Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices. Adenosine 63-72 interleukin 6 Mus musculus 20-24 11960643-6 2002 Thus, via A1 adenosine receptors, adenosine was found to be a strong inhibitor of splenic IL-6 secretion. Adenosine 13-22 interleukin 6 Mus musculus 90-94 35551509-5 2022 Mechanistically, KLB interacts with and stabilizes the cytokine receptor subunit GP130 by blockage of ubiquitin-dependent lysosomal degradation, thereby facilitating interleukin-6-evoked STAT3-HIF1alpha signaling, which in turn transactivates a cluster of glycolytic genes for adenosine triphosphate production and GSIS. Adenosine 277-286 interleukin 6 Mus musculus 166-179 30587074-3 2018 This study aimed to evaluate the effects of inflammatory stimuli (IL-6, LPS), uric acid, hyperglycemia, fatty acids, flavonoids, statins and nonsteroidal anti-inflammatory drugs on cellular concentration of adenosine triphosphate (ATP), adenosine diphosphate (ADP) and nicotinamide adenine dinucleotide (NAD+) in cultured endothelial cells. Adenosine 207-216 interleukin 6 Mus musculus 66-70 31050560-8 2019 This suggests the presence of a targetable adenosine-A2bR-IL-6-axis triggered by adenosine formed by the ischemic heart. Adenosine 43-52 interleukin 6 Mus musculus 58-62 31050560-8 2019 This suggests the presence of a targetable adenosine-A2bR-IL-6-axis triggered by adenosine formed by the ischemic heart. Adenosine 81-90 interleukin 6 Mus musculus 58-62 31050560-11 2019 This suggests an important adenosine-IL-6 axis, which is controlled by A2bR via local adenosine. Adenosine 27-36 interleukin 6 Mus musculus 37-41 31050560-11 2019 This suggests an important adenosine-IL-6 axis, which is controlled by A2bR via local adenosine. Adenosine 86-95 interleukin 6 Mus musculus 37-41 23225885-9 2013 CVT-6883 and genetic deletion of A(2B)AR significantly reduced adenosine-mediated IL-6 production. Adenosine 63-72 interleukin 6 Mus musculus 82-86 28893353-2 2017 Several liver cell types can secrete IL-6 following activation by various signaling molecules including circulating adenosine. Adenosine 116-125 interleukin 6 Mus musculus 37-41 28893353-3 2017 The aims of this study were to assess whether adenosine can induce IL-6 secretion by cholangiocytes via the A2b adenosine receptor (A2bAR) and to determine the effect of A2bAR-sensitive IL-6 release on injury response in biliary cirrhosis. Adenosine 46-55 interleukin 6 Mus musculus 67-71 28893353-7 2017 Adenosine induced IL-6 mRNA expression and protein secretion via A2bAR activation. Adenosine 0-9 interleukin 6 Mus musculus 18-22 28893353-11 2017 Extracellular adenosine induces cholangiocyte IL-6 release via the A2bAR. Adenosine 14-23 interleukin 6 Mus musculus 46-50 28893353-13 2017 Adenosine upregulates IL-6 release by cholangiocytes via the A2bAR in a calcium-sensitive fashion. Adenosine 0-9 interleukin 6 Mus musculus 22-26 26527068-9 2016 Increased adenosine levels were associated with elevation of IL-6 and IL-17, which are important inflammatory cytokines in pulmonary fibrosis. Adenosine 10-19 interleukin 6 Mus musculus 61-65 26527068-10 2016 These results demonstrate that extracellular adenosine levels are closely associated with the progression of experimental pulmonary fibrosis and that this signaling pathway may mediate fibrosis by regulating IL-6 and IL-17 production. Adenosine 45-54 interleukin 6 Mus musculus 208-212 24407238-8 2014 In vitro biochemical analysis revealed that adenosine directly attenuated recruitment of NF-kappaB to the TNF-alpha and interleukin-6 promoters. Adenosine 44-53 interleukin 6 Mus musculus 120-133 23922379-8 2013 In contrast to its stimulatory effect on IL-10-induced STAT3 activation, adenosine inhibited IL-6-induced STAT3 phosphorylation and SAA3 expression. Adenosine 73-82 interleukin 6 Mus musculus 93-97 23916894-6 2013 Cultured astrocytes from wildtype mice showed increased adenosine release in response to interleukin-6 and the hippocampus of wildtype mice had increased adenosine production 28 days after EAE induction, but the ALKO mutation abolished the increase in both conditions. Adenosine 56-65 interleukin 6 Mus musculus 89-102 21767631-12 2011 The co-transmitter adenosine stimulated IL-6 release via A1-adenosine receptors but no influence was recognized on TGF-beta. Adenosine 19-28 interleukin 6 Mus musculus 40-44 21511827-6 2011 Finally, both genetic and pharmacologic approaches showed that the inflammatory cytokine IL-6 mediates adenosine-induced renal fibrosis downstream of A(2B)R. Taken together, these data suggest that A(2B)R-mediated induction of IL-6 contributes to renal fibrogenesis and shows potential therapeutic targets for CKD. Adenosine 103-112 interleukin 6 Mus musculus 89-93 21511827-6 2011 Finally, both genetic and pharmacologic approaches showed that the inflammatory cytokine IL-6 mediates adenosine-induced renal fibrosis downstream of A(2B)R. Taken together, these data suggest that A(2B)R-mediated induction of IL-6 contributes to renal fibrogenesis and shows potential therapeutic targets for CKD. Adenosine 103-112 interleukin 6 Mus musculus 227-231