PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22575326-3	2012	We reviewed and identified experimental animal literature from which we developed a low-dose, linear model of PCB body burdens and decrements in free thyroxine (FT(4)) and total thyroxine (TT(4)), accounting for 33 PCB congeners; extrapolated the dose-response from animals to humans; and compared the animal dose-response to the dose-response of PCB body burdens and TH changes from eleven human epidemiological studies.	Thyroxine	150-159	pyruvate carboxylase	Homo sapiens	110-113	
28953452-13	2017	PCB congeners were statistically significantly associated with greater total and free thyroxine and total triiodothyronine among women and with total and free triiodothyronine among men in lipid-standardized models.	Thyroxine	86-95	pyruvate carboxylase	Homo sapiens	0-3	
22575326-3	2012	We reviewed and identified experimental animal literature from which we developed a low-dose, linear model of PCB body burdens and decrements in free thyroxine (FT(4)) and total thyroxine (TT(4)), accounting for 33 PCB congeners; extrapolated the dose-response from animals to humans; and compared the animal dose-response to the dose-response of PCB body burdens and TH changes from eleven human epidemiological studies.	Thyroxine	150-159	pyruvate carboxylase	Homo sapiens	215-218	
22575326-3	2012	We reviewed and identified experimental animal literature from which we developed a low-dose, linear model of PCB body burdens and decrements in free thyroxine (FT(4)) and total thyroxine (TT(4)), accounting for 33 PCB congeners; extrapolated the dose-response from animals to humans; and compared the animal dose-response to the dose-response of PCB body burdens and TH changes from eleven human epidemiological studies.	Thyroxine	150-159	pyruvate carboxylase	Homo sapiens	215-218	
22575326-3	2012	We reviewed and identified experimental animal literature from which we developed a low-dose, linear model of PCB body burdens and decrements in free thyroxine (FT(4)) and total thyroxine (TT(4)), accounting for 33 PCB congeners; extrapolated the dose-response from animals to humans; and compared the animal dose-response to the dose-response of PCB body burdens and TH changes from eleven human epidemiological studies.	Thyroxine	178-187	pyruvate carboxylase	Homo sapiens	110-113	
17938741-2	2007	Furthermore, prenatal exposure to some PCB congeners and commercial mixtures has been shown to decrease free and total thyroxine (T(4)) blood levels in animals.	Thyroxine	119-128	pyruvate carboxylase	Homo sapiens	39-42	
18550560-4	2008	After adjustment for covariates, seven of the 19 PCB congeners detected in more than 75% of participants and the sum of those congeners were negatively associated with free thyroxine concentrations.	Thyroxine	173-182	pyruvate carboxylase	Homo sapiens	49-52	
8033869-8	1994	We offer some simple molecular recognition models to account for the importance of these different structural features in the structure-activity relationships that permit one to express PCB reactivities in terms of dioxin, thyroxine, and estradiol equivalents.	Thyroxine	223-232	pyruvate carboxylase	Homo sapiens	186-189	
21782738-4	2004	Both with and without statistical adjustment for other toxicants, as well as age, sex and lipid levels, several indicators of PCB burden are significantly, negatively related to levels of free thyroxine and total thyroxine, and positively to thyrotropin.	Thyroxine	193-202	pyruvate carboxylase	Homo sapiens	126-129	
21782738-4	2004	Both with and without statistical adjustment for other toxicants, as well as age, sex and lipid levels, several indicators of PCB burden are significantly, negatively related to levels of free thyroxine and total thyroxine, and positively to thyrotropin.	Thyroxine	213-222	pyruvate carboxylase	Homo sapiens	126-129	
11748036-4	2001	Serum PCB level and consumption of Great Lakes fish are associated with significantly lower levels of thyroxine (T(4)) and free thyroxine index (FTI) in women and with significantly lower levels of T(4) in men.	Thyroxine	102-111	pyruvate carboxylase	Homo sapiens	6-9	
11748036-4	2001	Serum PCB level and consumption of Great Lakes fish are associated with significantly lower levels of thyroxine (T(4)) and free thyroxine index (FTI) in women and with significantly lower levels of T(4) in men.	Thyroxine	128-137	pyruvate carboxylase	Homo sapiens	6-9	
11940460-10	2002	In Nunavik and Lower North Shore samples, free thyroxine (T4) concentrations (log transformed) were negatively correlated with the sum of quantitated chlorinated phenolic compounds (sum PCP and sigma HO-PCBs; r = -0.47, p = 0.01, n = 20) and were not correlated with any PCB congeners or sigma PCBs.	Thyroxine	47-56	pyruvate carboxylase	Homo sapiens	203-206	
3138502-6	1987	Using conservative assumptions based on experimental data, our calculations indicate that PCB concentrations normally found in humans can effect significant increases in free thyroxine levels in serum by competing with serum thyroid hormone binding proteins.	Thyroxine	175-184	pyruvate carboxylase	Homo sapiens	90-93