PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31731779-0	2019	Penta-1,2,3,4,6-O-Galloyl-beta-D-Glucose Inhibits UVB-Induced Photoaging by Targeting PAK1 and JNK1.	beta-penta-O-galloyl-glucose	0-40	mitogen-activated protein kinase 8	Homo sapiens	95-99	
31731779-5	2019	PGG suppressed PAK1 and JNK1 kinase activities, and directly bound both PAK1 in an ATP-competitive manner and JNK1 in an ATP-noncompetitive manner.	beta-penta-O-galloyl-glucose	0-3	mitogen-activated protein kinase 8	Homo sapiens	24-28	
31731779-5	2019	PGG suppressed PAK1 and JNK1 kinase activities, and directly bound both PAK1 in an ATP-competitive manner and JNK1 in an ATP-noncompetitive manner.	beta-penta-O-galloyl-glucose	0-3	mitogen-activated protein kinase 8	Homo sapiens	110-114	
31731779-7	2019	Overall, these results indicate that PGG exhibits anti-photoaging effects in vitro and in vivo by the suppression of PAK1 and JNK1 kinase activities, and may be useful for the prevention of skin aging.	beta-penta-O-galloyl-glucose	37-40	mitogen-activated protein kinase 8	Homo sapiens	126-130	
22771329-4	2012	Interestingly, a significant activation of JNK by PGG was observed by MULTIPLEX assay and Western blotting.	beta-penta-O-galloyl-glucose	50-53	mitogen-activated protein kinase 8	Homo sapiens	43-46	
22771329-5	2012	Conversely, JNK inhibitor D-JNKi suppressed the cleavages of caspase 3 and PARP induced by PGG in K562 cells.	beta-penta-O-galloyl-glucose	91-94	mitogen-activated protein kinase 8	Homo sapiens	12-15	
22771329-7	2012	Of note, ROS inhibitor acetyl-L-cysteine (NAC) reversed JNK-dependent apoptosis and DAXX inhibition induced by PGG.	beta-penta-O-galloyl-glucose	111-114	mitogen-activated protein kinase 8	Homo sapiens	56-59	
22771329-8	2012	Overall, these findings suggest that ROS-dependent JNK activation and DAXX downregulation are critically involved in PGG-induced apoptosis in K562 cells.	beta-penta-O-galloyl-glucose	117-120	mitogen-activated protein kinase 8	Homo sapiens	51-54	
24389959-9	2014	Furthermore, our data showed that activation of MAPK8/9/10 (mitogen-activated protein kinase 8/9/10/c-Jun N-terminal kinases) was an essential upstream signal for PGG-induced autophagy.	beta-penta-O-galloyl-glucose	163-166	mitogen-activated protein kinase 8	Homo sapiens	48-58	
24389959-9	2014	Furthermore, our data showed that activation of MAPK8/9/10 (mitogen-activated protein kinase 8/9/10/c-Jun N-terminal kinases) was an essential upstream signal for PGG-induced autophagy.	beta-penta-O-galloyl-glucose	163-166	mitogen-activated protein kinase 8	Homo sapiens	60-99