PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1775178-0 1991 Regulation of beta-endorphin biosynthesis in the brain: different effects of morphine pelleting and repeated stress. Morphine 77-85 proopiomelanocortin Homo sapiens 14-28 2577268-5 1989 The metENK actions appear mediated via a mu-opiate receptor; morphine and D-ala-metENK-amide (DALA), a stable analog of metENK, are agonists. Morphine 61-69 proopiomelanocortin Homo sapiens 4-10 2130014-2 1990 Morphine was used as a pharmacological mimicry of the stress-induced ACTH outflow in the post-injection period of 10-45 min. Morphine 0-8 proopiomelanocortin Homo sapiens 69-73 35183689-2 2022 Along with pharmacologic evidence of the effects of morphine and naloxone administered immediately after training in avoidance tasks and with the demonstration of medial-basal hypothalamus beta-endorphin release after novelty detection, it was hypothesized that an endogenous opioid state present in the labile period of consolidation will be part of the memory of the newly acquired information. Morphine 52-60 proopiomelanocortin Homo sapiens 189-203 2483754-0 1989 The developmental pattern of met-enkephalin innervation is altered in animals perinatally exposed to morphine. Morphine 101-109 proopiomelanocortin Homo sapiens 29-43 2416296-0 1985 [Levels of 5-HIAA and beta-endorphin in CSF after intrathecal morphine]. Morphine 62-70 proopiomelanocortin Homo sapiens 22-36 2971429-0 1987 [The response of plasma beta-endorphin to postoperative pain after epidural morphine]. Morphine 76-84 proopiomelanocortin Homo sapiens 24-38 3035015-5 1987 The modulatory effects of morphine and beta-END on peripheral blood mononuclear cell oxygen metabolism appeared to involve a classical opioid receptor, because opioid activity was blocked by naloxone and was not observed with N-acetylated-beta-END. Morphine 26-34 proopiomelanocortin Homo sapiens 239-247 2932121-1 1985 Previous studies have documented a reduction in plasma beta-endorphin levels with the use of various analgesic techniques in labor, such as segmental epidural anesthesia or intrathecal morphine. Morphine 185-193 proopiomelanocortin Homo sapiens 55-69 2963966-7 1988 Consistently with our observations in human newborn and the neurological dysfunctions we observed in them, the concentrations of both the peptides are significantly increased in the hypothalamus of fetuses and newborn of morphine-treated mothers, while in the pituitary only beta-endorphin concentrations are increased. Morphine 221-229 proopiomelanocortin Homo sapiens 275-289 3036903-10 1987 We conclude that glucocorticoids and morphine agonists exert interactive inhibitory effects on ACTH release in humans, probably by virtue of their suppression of CRH release from the hypothalamus. Morphine 37-45 proopiomelanocortin Homo sapiens 95-99 3033966-9 1987 Oral morphine not only suppressed basal hormone levels (P less than 0.02), but also the peak response to hCRH compared with placebo (cortisol: 270 +/- 50 vs 559 +/- 80 nmol/l; ACTH: 5.1 +/- 1.5 vs 13.1 +/- 2.7 pmol/l; ir beta-endorphin: 48.5 +/- 8.7 vs 88 +/- 14 pmol/l; mean +/- SEM, P less than 0.02). Morphine 5-13 proopiomelanocortin Homo sapiens 221-235 2951622-2 1987 All 3 experimental approaches resulted in a decrease of the analgesia induced by morphine, thus suggesting that beta-endorphin is involved in the effect of morphine. Morphine 81-89 proopiomelanocortin Homo sapiens 112-126 2951622-2 1987 All 3 experimental approaches resulted in a decrease of the analgesia induced by morphine, thus suggesting that beta-endorphin is involved in the effect of morphine. Morphine 156-164 proopiomelanocortin Homo sapiens 112-126 2938526-0 1986 [Changes in the beta-endorphin plasma levels caused by epidural morphine analgesia during the early postoperative period in cancer patients]. Morphine 64-72 proopiomelanocortin Homo sapiens 16-30 6087663-0 1984 Effect of intrathecal morphine during labor on maternal plasma beta-endorphin levels. Morphine 22-30 proopiomelanocortin Homo sapiens 63-77 2933175-1 1985 The concentrations of human immunoreactive beta-endorphin-like substances in plasma were measured as a means of determining the effects of general anesthesia and surgical stress on the endogenous morphine-like substances. Morphine 196-204 proopiomelanocortin Homo sapiens 43-57 6087372-0 1984 Loss of sensitivity to morphine induced by prolonged ACTH treatment. Morphine 23-31 proopiomelanocortin Homo sapiens 53-57 6087372-1 1984 The effect of long term ACTH treatment on some actions of morphine were studied. Morphine 58-66 proopiomelanocortin Homo sapiens 24-28 6087372-3 1984 ACTH caused a delayed inhibition of the morphine induced increase in growth hormone secretion demonstrable 24 hr after the last hormone injection. Morphine 40-48 proopiomelanocortin Homo sapiens 0-4 6087372-4 1984 The morphine induced increase of striatal DOPAC (3,4-dihydroxyphenylacetic acid) content was also inhibited by ACTH treatment, however, neither the analgesia, nor the hypermotility caused by morphine were affected. Morphine 4-12 proopiomelanocortin Homo sapiens 111-115 6087663-3 1984 Plasma beta-endorphin levels decreased significantly (p less than 0.005) after intrathecal morphine from 76 +/- 9.7 to 46.3 +/- 9.1 fmol/ml (mean +/- SE), possibly because of decreased pituitary beta-endorphin secretion in response to alleviation of labor pain. Morphine 91-99 proopiomelanocortin Homo sapiens 7-21 6087663-1 1984 Plasma beta-endorphin was measured in 16 patients in labor prior to and after complete onset of analgesia with 1 mg of morphine administered intrathecally. Morphine 119-127 proopiomelanocortin Homo sapiens 7-21 6321202-0 1983 Hypothalamic ACTH and MSH levels increase in morphine tolerance and decrease after morphine withdrawal. Morphine 45-53 proopiomelanocortin Homo sapiens 13-17 6329787-0 1984 Effects of beta-endorphin fragment 6-31 on morphine- and beta-endorphin-induced growth hormone and prolactin release. Morphine 43-51 proopiomelanocortin Homo sapiens 11-25 6321202-0 1983 Hypothalamic ACTH and MSH levels increase in morphine tolerance and decrease after morphine withdrawal. Morphine 45-53 proopiomelanocortin Homo sapiens 22-25 6321202-0 1983 Hypothalamic ACTH and MSH levels increase in morphine tolerance and decrease after morphine withdrawal. Morphine 83-91 proopiomelanocortin Homo sapiens 13-17 6321202-0 1983 Hypothalamic ACTH and MSH levels increase in morphine tolerance and decrease after morphine withdrawal. Morphine 83-91 proopiomelanocortin Homo sapiens 22-25 6287193-3 1982 Evidence is presented in this paper that [3H]etorphine can be used to label selectively the morphine receptor and that the inhibitory dissociation constants (KI) of morphine, etorphine, and human beta-endorphin for the [3H]etorphine binding site closely approximate the concentration of these drugs which produce a half-maximal decrease in the number of enkephalin receptors. Morphine 92-100 proopiomelanocortin Homo sapiens 196-210 6286042-7 1982 Animals made tolerant to beta-endorphin in this fashion showed a significantly reduced response to an otherwise active dose of intrathecal morphine, indicating evidence for cross tolerance. Morphine 139-147 proopiomelanocortin Homo sapiens 25-39 6822955-6 1983 Treatment of hypophysectomized animals with s.c. adrenocorticotropic hormone decreased responsiveness to the antinociceptive and the hyperthermic actions of morphine. Morphine 157-165 proopiomelanocortin Homo sapiens 49-76 6822955-11 1983 Adrenocorticotropic hormone, when administered 30 min before morphine, showed reproducible but statistically nonsignificant suppression of tolerance development. Morphine 61-69 proopiomelanocortin Homo sapiens 0-27 6294192-5 1982 Following epidural morphine, the plasma ACTH levels significantly decreased in the effective cases, and insignificantly increased in the ineffective cases. Morphine 19-27 proopiomelanocortin Homo sapiens 40-44 6294192-7 1982 We concluded that patterns of PRL and ACTH releases following epidural morphine were correspondent with the analgesic effect, and that appearance of amelioration of pain following epidural morphine may depend upon the dopaminergic mechanism. Morphine 71-79 proopiomelanocortin Homo sapiens 38-42 6258928-2 1980 Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Morphine 25-33 proopiomelanocortin Homo sapiens 0-14 6276911-0 1982 Stress-induced plasma beta-endorphin immunoreactivity may predict postoperative morphine usage. Morphine 80-88 proopiomelanocortin Homo sapiens 22-36 6276911-5 1982 Both presurgery and mean surgery plasma beta-endorphin levels significantly predict morphine requirement, and similar, although not so strong, correlations are found for cortisol. Morphine 84-92 proopiomelanocortin Homo sapiens 40-54 6276911-7 1982 When multiple regression analysis is used, the variables of plasma beta-endorphin and age predict 70% of the variance in individual morphine requirements. Morphine 132-140 proopiomelanocortin Homo sapiens 67-81 6297355-4 1982 Following microinjection into the PAG, beta-endorphin exerted an inhibitory, and ACTH an excitatory, action, i.e., each duplicated one of morphine"s dual actions. Morphine 138-146 proopiomelanocortin Homo sapiens 39-53 6297355-4 1982 Following microinjection into the PAG, beta-endorphin exerted an inhibitory, and ACTH an excitatory, action, i.e., each duplicated one of morphine"s dual actions. Morphine 138-146 proopiomelanocortin Homo sapiens 81-85 6297355-5 1982 These results indicated that receptors for the endogenously occurring peptides, beta-endorphin and ACTH, may play a role in morphine"s potent pharmacological actions. Morphine 124-132 proopiomelanocortin Homo sapiens 80-94 6297355-5 1982 These results indicated that receptors for the endogenously occurring peptides, beta-endorphin and ACTH, may play a role in morphine"s potent pharmacological actions. Morphine 124-132 proopiomelanocortin Homo sapiens 99-103 7395604-0 1980 Suppression of morphine abstinence in heroin addicts by beta-endorphin. Morphine 15-23 proopiomelanocortin Homo sapiens 56-70 6249078-0 1980 Inhibition of development of tolerance to morphine by a peptide related to ACTH. Morphine 42-50 proopiomelanocortin Homo sapiens 75-79 537466-0 1979 Morphine like activity of some new Met-enkephalin analogues. Morphine 0-8 proopiomelanocortin Homo sapiens 35-49 228824-4 1979 The discovery that morphine-like substances are part of the C-terminal fragment of beta-LPH brought an additional important biological side product. Morphine 19-27 proopiomelanocortin Homo sapiens 83-91 7443728-11 1980 Long-term morphine treatment (30 days) decreased enkephalin and beta-endorphin content in some brain areas and in the intermediate/posterior pituitary lobe but not in the anterior lobe. Morphine 10-18 proopiomelanocortin Homo sapiens 64-78 37395-0 1979 Attenuation of morphine tolerance and dependence by alpha-melanocyte stimulating hormone(alpha-MSH). Morphine 15-23 proopiomelanocortin Homo sapiens 52-88 37395-0 1979 Attenuation of morphine tolerance and dependence by alpha-melanocyte stimulating hormone(alpha-MSH). Morphine 15-23 proopiomelanocortin Homo sapiens 89-98 440006-0 1979 Effects of morphine and beta-endorphin on basal and elevated plasma levels of alpha-MSH and vasopressin. Morphine 11-19 proopiomelanocortin Homo sapiens 78-87 222147-1 1979 The beta-endorphin residue of pituitary beta-lipotropin hormone, which regulates utilization and storage of body fat, is several times more potent than morphine in raising pain tolerance. Morphine 152-160 proopiomelanocortin Homo sapiens 4-18 581358-3 1978 Matching morphine and beta-endorphin doses such that approximately equal submaximal submaximal effects occurred, it was observed that the antinociception produced by beta-endorphin lasted approximately three times longer than that produced by morphine. Morphine 9-17 proopiomelanocortin Homo sapiens 166-180 318190-4 1978 In a more limited study using peripheral injections, it was determined that (D-Ala2)-Met-enkephalin at doses of 400 nanomoles/kg, like morphine sulfate, was more effective in reducing DV"s, than an equimolar dose of beta-endorphin. Morphine 135-151 proopiomelanocortin Homo sapiens 85-99 581358-7 1978 These data and those derived from previous work based on the pA2 suggest that the interaction of morphine, certain pentapeptides, and beta-endorphin is the same with regard to the spinal opiate receptor population mediating behaviorally defined analgesia. Morphine 97-105 proopiomelanocortin Homo sapiens 134-148 209366-0 1978 Effect of naloxone on morphine-induced changes in ACTH, corticosterone and cyclic nucleotides. Morphine 22-30 proopiomelanocortin Homo sapiens 50-54 19605229-2 1978 A previous injection of beta-endorphin, (D-Phe(7))ACTH(4-10), or morphine, also reduces the behavioral response to a subsequent injection of ACTH. Morphine 65-73 proopiomelanocortin Homo sapiens 141-145 78323-1 1978 beta-endorphin is a brain peptide with potent morphine-like activity structurally related to the anterior pituitary hormone beta-lipotrophin (beta-L.P.H.). Morphine 46-54 proopiomelanocortin Homo sapiens 0-14 13251225-0 1955 Studies on the mechanism of stimulation of ACTH secretion with the aid of morphine as a blocking agent. Morphine 74-82 proopiomelanocortin Homo sapiens 43-47 590341-3 1977 These observations provide additional evidence that beta-MSH functions in the nervous system as a modulator, and may help explain actions of beta-MSH in modifying acquisition of conditioned avoidance responses as well as its interaction with drugs such as morphine. Morphine 256-264 proopiomelanocortin Homo sapiens 52-60 590341-3 1977 These observations provide additional evidence that beta-MSH functions in the nervous system as a modulator, and may help explain actions of beta-MSH in modifying acquisition of conditioned avoidance responses as well as its interaction with drugs such as morphine. Morphine 256-264 proopiomelanocortin Homo sapiens 141-149 279260-0 1977 Isolation, structure, synthesis and morphine-like activity of beta-endorphin from human pituitary glands. Morphine 36-44 proopiomelanocortin Homo sapiens 62-76 279264-0 1977 A betaLPH precursor model: recent developments concerning morphine-like substances. Morphine 58-66 proopiomelanocortin Homo sapiens 2-9 279264-7 1977 Thus far, these morphine-like peptides seem not to cross the blood-brain barrier in rats; it is conceivable (neurophysiologists will need to look into it) that an upward circulatory process could bring beta-endorphin into the brain where it is concentrated in different regions as either native or degraded products both of which have similar activities. Morphine 16-24 proopiomelanocortin Homo sapiens 202-216 279264-11 1977 The major conclusion of our most recent studies on the biosynthesis of betaLPH and its related peptides have led us to the first in vitro biosynthesis of an endogenous morphine-like substance. Morphine 168-176 proopiomelanocortin Homo sapiens 71-78 905630-2 1977 This effect of beta-endorphin is compatible with increased striatal dopamine turnover and is similar to the effect noted previously with morphine administration. Morphine 137-145 proopiomelanocortin Homo sapiens 15-29 892989-0 1977 beta-endorphin: synthesis and morphine-like activity of analogs with D-amino acid residues in positions 1, 2, 4, and 5. Morphine 30-38 proopiomelanocortin Homo sapiens 0-14 4363913-0 1973 Effects of morphine and related drugs on the corticotrophin (ACTH)-stress reaction. Morphine 11-19 proopiomelanocortin Homo sapiens 61-65 4363914-0 1973 Antagonism between morphine and the polypeptides ACTH, ACTH1-24 and beta-MSH in the nervous system. Morphine 19-27 proopiomelanocortin Homo sapiens 49-53 4363914-0 1973 Antagonism between morphine and the polypeptides ACTH, ACTH1-24 and beta-MSH in the nervous system. Morphine 19-27 proopiomelanocortin Homo sapiens 68-76 13688942-0 1961 The reversal by nalorphine of the inhibitory effect of morphine on the secretion of adrenocorticotropic hormone in stress. Morphine 55-63 proopiomelanocortin Homo sapiens 84-111 200175-0 1977 beta-Endorphin: a pituitary peptide with potent morphine-like activity. Morphine 48-56 proopiomelanocortin Homo sapiens 0-14 195688-0 1977 Primary structure and morphine-like activity of human beta-endorphin. Morphine 22-30 proopiomelanocortin Homo sapiens 54-68 4371024-0 1974 Antagonism of morphine by beta-melanocyte-stimulating hormone and by tetracosactin. Morphine 14-22 proopiomelanocortin Homo sapiens 26-61 32669986-10 2019 Results: Beta-endorphin is an abundant endorphin, potent than morphine, synthesized and secreted in the anterior pituitary gland, it is a precursor of POMC (proopiomelanocortin). Morphine 62-70 proopiomelanocortin Homo sapiens 9-23 32669986-12 2019 Conclusion: Beta endorphin is an abundant endogenous morphine used for natural holistic preventive, therapeutic, promotive, and palliative treatment of cancer without adverse effects and inexpensive. Morphine 53-61 proopiomelanocortin Homo sapiens 12-26 9878818-9 1999 Furthermore, morphine, in a dose-dependent manner, increased the hemolymph levels of alpha-MSH and ACTH (1-39) in a naloxone and phosphoramidon antagonizable manner, indicating a neutral endopeptidase (24.11; NEP) mediated cleavage. Morphine 13-21 proopiomelanocortin Homo sapiens 91-94 24398105-7 2014 Pre-treatment with CRF1 receptor antagonist significantly reduced morphine withdrawal-induced increases in plasma adrenocorticotropic hormone (ACTH) levels, NA turnover and TH phosphorylation at Ser31 in the right ventricle. Morphine 66-74 proopiomelanocortin Homo sapiens 114-141 24398105-7 2014 Pre-treatment with CRF1 receptor antagonist significantly reduced morphine withdrawal-induced increases in plasma adrenocorticotropic hormone (ACTH) levels, NA turnover and TH phosphorylation at Ser31 in the right ventricle. Morphine 66-74 proopiomelanocortin Homo sapiens 143-147 23391885-0 2012 Intermittent subcutaneous morphine regimen for postoperative pain management following abdominal hysterectomy regarding morphine- and beta-endorphin systemic concentrations. Morphine 26-34 proopiomelanocortin Homo sapiens 134-148 20926668-7 2010 Met-enkephalin, but not the mu-selective (DAMGO) and delta-selective (DPDPE) opioid receptor agonists, mimicked the effect of morphine, suggesting involvement of a heterodimeric opioid receptor complex. Morphine 126-134 proopiomelanocortin Homo sapiens 0-14 18183621-1 2008 Our previous study showed that YGGFMKKKFMRFamide (YFa), a chimeric peptide of Met-enkephalin, and Phe-Met-Arg-Phe-NH2 induced naloxone-reversible antinociception and attenuated the development of tolerance to morphine analgesia. Morphine 209-217 proopiomelanocortin Homo sapiens 78-92 16289330-1 2006 Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Morphine 145-153 proopiomelanocortin Homo sapiens 10-24 16868614-13 2004 Plasma BE levels increased with improved pain control with each of the four analgesic modalities, including oral and epidural morphine. Morphine 126-134 proopiomelanocortin Homo sapiens 7-9 11245969-2 2001 Morphine binding is displaceable by beta-endorphin (1--31) and (--)-naloxone but not DAMGO. Morphine 0-8 proopiomelanocortin Homo sapiens 36-50 20212915-8 2010 Proposition #5 The first 3 amino acid sequences of beta endorphin (l-try-gly-gly) and the active opioid dipeptide, l-tyr-pro, (as a result of a peptide turn and zwitterion bonding) form a virtual piperazine-like ring which is similar in size, shape and location to the heterocyclic rings of morphine, meperidine, and methadone. Morphine 291-299 proopiomelanocortin Homo sapiens 51-65 18977279-9 2009 In receptor-mediated G-protein activation assays measured by the stimulation of [(35)S]GTPgammaS binding, Met-enkephalin produced the highest stimulation followed by Leu-enkephalin, Ile-enkephalin and Phe-enkephalin, whereas the least efficacious among these endogenous peptides was still more effective than the prototype opiate agonist morphine in these functional tests. Morphine 338-346 proopiomelanocortin Homo sapiens 106-120 18930087-0 2008 Lack of tolerance and morphine-induced cross-tolerance to the analgesia of chimeric peptide of Met-enkephalin and FMRFa. Morphine 22-30 proopiomelanocortin Homo sapiens 95-109 17692472-2 2008 Met-enkephalin, one of the endogenous opioid peptides, can bind to the same receptors to which morphine binds, triggering similar receptor-mediated effects. Morphine 95-103 proopiomelanocortin Homo sapiens 0-14 17692472-5 2008 Analogous to the effect of morphine on the hepatitis C-replicon containing liver cells, we hypothesize that Met-enkephalin enhances the replication of the hepatitis C virus in liver cells, and that it interferes with the antiviral effect of interferon, contributing to the lack of efficacy of this medication in the treatment of this viral infection in some patients. Morphine 27-35 proopiomelanocortin Homo sapiens 108-122 9878818-9 1999 Furthermore, morphine, in a dose-dependent manner, increased the hemolymph levels of alpha-MSH and ACTH (1-39) in a naloxone and phosphoramidon antagonizable manner, indicating a neutral endopeptidase (24.11; NEP) mediated cleavage. Morphine 13-21 proopiomelanocortin Homo sapiens 99-103 9666265-4 1998 Binding of 3H-morphine to the receptor is displaced by morphine, etorphine, naloxone, diprenorphine and morphine 6-glucuronide, but not by morphine 3-glucuronide, fentanyl, benzomorphans, enkephalins, dynorphin, beta-endorphin, endomorphin-1, other opioid peptides or nociceptin (orphanin FQ). Morphine 14-22 proopiomelanocortin Homo sapiens 212-226 9476677-2 1997 Furthermore, morphine increases the secretion of CRH, ACTH and glucocorticoids, i.e. substances with inhibitory effects on the immune system. Morphine 13-21 proopiomelanocortin Homo sapiens 54-58 9228653-2 1997 Thus, we investigated 8 pain patients prior to and during prolonged oral treatment with 30-240 mg of sustained release morphine for plasma concentrations of adrenocorticotropic hormone and serum concentrations of cortisol. Morphine 119-127 proopiomelanocortin Homo sapiens 157-184 7544552-6 1995 Those with beta-EP concentrations > 153 pg/mL had significantly longer analgesia (P < 0.01), and lower utilization of morphine in the first postoperative day (P < 0.01). Morphine 124-132 proopiomelanocortin Homo sapiens 11-18 9137321-2 1997 Beta-endorphin is a neuroendocrine peptide, with morphine-like effects, produced by anterior pituitary, cells of the immune system, and synovial cells. Morphine 49-57 proopiomelanocortin Homo sapiens 0-14 8750881-8 1995 Prenatal morphine treatment significantly increased proenkephalin mRNA levels and decreased met-enkephalin levels in striatum of newborns. Morphine 9-17 proopiomelanocortin Homo sapiens 92-106 8750881-10 1995 These data indicate that prenatal morphine treatment may increase met-enkephalin release and/or cause inhibition at the level of translation. Morphine 34-42 proopiomelanocortin Homo sapiens 66-80 7641799-1 1995 The small cell lung carcinoma cell line U-1690 bound beta-endorphin via nonopioid binding sites also recognized by the C-terminal part of this opioid peptide Lys-Lys-Gly-Glu, but not by opiate alkaloids such as naloxone and morphine or other opioid peptides. Morphine 224-232 proopiomelanocortin Homo sapiens 53-67 7957911-3 1994 The Ca(2+)-bound conformation of Met-enkephalin was found to have an overall shape that matched well with that of morphine. Morphine 114-122 proopiomelanocortin Homo sapiens 33-47 8000445-6 1994 Morphine (20 mg/kg ip) increased the level of LENK in the hypothalamus, decreased the concentrations of MENK in the medulla oblongata and in the cervical part of the spinal cord, and increased the level of this neuropeptide in the thoracic part of the spinal cord. Morphine 0-8 proopiomelanocortin Homo sapiens 104-108 8021759-3 1994 There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%. Morphine 116-124 proopiomelanocortin Homo sapiens 133-147 8485623-25 1993 Its ability to inhibit the action of morphine and DPDPE suggests that it may attenuate beta-endorphin action by an interaction with mu- and/or delta-opioid receptors. Morphine 37-45 proopiomelanocortin Homo sapiens 87-101 19912904-0 1993 Prolonged Activation of c-fos and Optimal Activation of Pro-opiomelanocortin mRNA after Repeated Morphine Exposure in SH-SY5Y Cells. Morphine 97-105 proopiomelanocortin Homo sapiens 56-76 8297446-6 1993 The patients undergoing epidural morphine analgesia in combination with slight neuroleptanaesthesia reached about five times higher levels of plasma concentration of beta-endorphin than the patients receiving neuroleptanaesthesia type II. Morphine 33-41 proopiomelanocortin Homo sapiens 166-180 19912904-1 1993 The time course of change in the mRNA concentrations of the proto-oncogene c-fos and pro-opiomelanocortin after two different methods of morphine treatment was examined in SH-SY5Y human neuroblastoma cells. Morphine 137-145 proopiomelanocortin Homo sapiens 85-105 8442811-9 1993 A significant reduction in serum beta-endorphin content was observed following the onset of morphine therapy. Morphine 92-100 proopiomelanocortin Homo sapiens 33-47 8442811-11 1993 Continuous morphine therapy appears to be effective in controlling neonatal postoperative pain, as suggested by subjective nursing observations and decreased serum beta-endorphin content. Morphine 11-19 proopiomelanocortin Homo sapiens 164-178 19912904-6 1993 Slot-blotting hybridization with a [(32)P]-POMC cRNA probe revealed that POMC mRNA was significantly activated at 6 h and remained significantly elevated up to 7 days in the cells with repeated morphine treatment. Morphine 194-202 proopiomelanocortin Homo sapiens 43-47 19912904-6 1993 Slot-blotting hybridization with a [(32)P]-POMC cRNA probe revealed that POMC mRNA was significantly activated at 6 h and remained significantly elevated up to 7 days in the cells with repeated morphine treatment. Morphine 194-202 proopiomelanocortin Homo sapiens 73-77 19912904-9 1993 These results indicate that repeated exposure to morphine induces a prolonged activation of c-fos mRNA which may be functionally related to the significant activation of POMC mRNA in SH-SY5Y cells. Morphine 49-57 proopiomelanocortin Homo sapiens 170-174 1445968-2 1992 Levels of BE are elevated by opioid antagonists such as naloxone and depressed by short-acting agonists such as heroin and morphine; they become normalized during steady-state methadone. Morphine 123-131 proopiomelanocortin Homo sapiens 10-12 7520295-2 1993 When an endogenous morphine, beta-endorphin was discovered ten years ago, the fact that this morphine is present in the brain and many other tissues suggested to neurobiologists that these peptide opiates play a role which goes beyond that of a simple modulator of the perception of pain. Morphine 19-27 proopiomelanocortin Homo sapiens 29-43 7520295-2 1993 When an endogenous morphine, beta-endorphin was discovered ten years ago, the fact that this morphine is present in the brain and many other tissues suggested to neurobiologists that these peptide opiates play a role which goes beyond that of a simple modulator of the perception of pain. Morphine 93-101 proopiomelanocortin Homo sapiens 29-43 1416198-0 1992 [Changes in the concentration of beta-endorphin in the cerebrospinal fluid due to morphine analgesia in incurable oncologic patients]. Morphine 82-90 proopiomelanocortin Homo sapiens 33-47 1416198-3 1992 Morphine analgesia is followed by beta-endorphin level elevation which directly depends on pain intensity and analgesia efficacy. Morphine 0-8 proopiomelanocortin Homo sapiens 34-48 1596757-3 1992 Morphine administration elicited an increase in immunoreactive ENK and beta-EP in both the N. accumbens and the amygdala, which was antagonized in each nucleus by perfusion with naloxone. Morphine 0-8 proopiomelanocortin Homo sapiens 71-78 1608292-0 1992 alpha N-acetyl human beta-endorphin-(1-31) alleviates the morphine withdrawal syndrome in rodents: a comparative study with clonidine. Morphine 58-66 proopiomelanocortin Homo sapiens 21-35 1409005-4 1992 It was found that microinjection of morphine increased the content of immunoreactive enkephalins (ir-ENK) and immunoreactive beta-endorphin (ir-beta-EP) in the perfusate of the PAG and the amygdala. Morphine 36-44 proopiomelanocortin Homo sapiens 125-139 1608292-1 1992 The potential effect of intracerebroventricular (icv) alpha N-acetyl human beta-endorphin-(1-31) on morphine dependence was examined in mice and rats. Morphine 100-108 proopiomelanocortin Homo sapiens 75-89 1608292-3 1992 After 72 h of chronic morphine, 1 mg/Kg sc naloxone precipitated in both species a withdrawal syndrome that was moderate in animals pretreated with the acetylated derivative of beta-endorphin. Morphine 22-30 proopiomelanocortin Homo sapiens 177-191 1608292-9 1992 Icv injections of the antagonist of alpha 2-adrenoceptors yohimbine prevented both clonidine and alpha N-acetyl beta-endorphin-(1-31) from reducing the jumping behaviour displayed by morphine-abstinent mice. Morphine 183-191 proopiomelanocortin Homo sapiens 112-126 1608292-10 1992 It is suggested that alpha N-acetyl beta-endorphin produces this alleviation of the morphine withdrawal syndrome by improving the efficiency of alpha 2-mediated agonist effects after acting on a neural substrate that is distinct from the mu opioid receptor binding site. Morphine 84-92 proopiomelanocortin Homo sapiens 36-50 1815211-2 1991 Intra-amygdaloid injection of morphine increased the release of enkephalins and beta-endorphin in the PAG and N. accumbens. Morphine 30-38 proopiomelanocortin Homo sapiens 80-94 1814247-1 1991 Beta-endorphin is a peptide with morphine-like effects produced primarily in the anterior lobe of the pituitary gland. Morphine 33-41 proopiomelanocortin Homo sapiens 0-14