PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27447626-6	2016	In addition, it was revealed that morphine causes severe constipation by increasing the AQP3 expression level in the colon.	Morphine	34-42	aquaporin 3 (Gill blood group)	Homo sapiens	88-92	
25766885-0	2015	Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion.	Morphine	0-8	aquaporin 3 (Gill blood group)	Homo sapiens	54-65	
25766885-2	2015	This study investigated the role of AQP3 in the colon in morphine-induced constipation.	Morphine	57-65	aquaporin 3 (Gill blood group)	Homo sapiens	36-40	
25766885-5	2015	The mechanism by which morphine increased AQP3 expression was examined in HT-29 cells.	Morphine	23-31	aquaporin 3 (Gill blood group)	Homo sapiens	42-46	
25766885-12	2015	The results suggest that morphine increases the AQP3 expression level in the colon, which promotes water absorption from the luminal side to the vascular side and causes constipation.	Morphine	25-33	aquaporin 3 (Gill blood group)	Homo sapiens	48-52	
25766885-13	2015	This study also showed that morphine-induced 5-HT secreted from the colon was taken into cells by SERT and activated PPARgamma, which subsequently increased AQP3 expression levels.	Morphine	28-36	aquaporin 3 (Gill blood group)	Homo sapiens	157-161