PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22066570-7 2012 Morphine enhanced IL-6 secretion and blunted MCP-2 secretion from HIV-infected h-mdms. Morphine 0-8 interleukin 6 Homo sapiens 18-22 22066570-6 2012 Chronic morphine exposure of HIV-infected h-mdms led to significant alterations in the secretion of IL-6 and monocyte chemoattractant protein 2 (MCP-2). Morphine 8-16 interleukin 6 Homo sapiens 100-104 22066570-10 2012 Morphine had a potentially additive effect on the HIV-induced production of IL-6 and delayed HIV-induced MCP-2 production. Morphine 0-8 interleukin 6 Homo sapiens 76-80 19865006-8 2009 Penetration of morphine metabolites into the central nervous system increased in proportion to the neuroinflammatory response as demonstrated by the positive correlation between cerebrospinal fluid interleukin-6 exposure and the area under the curve cerebrospinal fluid/plasma ratio for morphine-3-glucuronide (r = .49, p < .001) and morphine-6-glucuronide (r = .51, p < .001). Morphine 15-23 interleukin 6 Homo sapiens 198-211 20564181-8 2010 In this context, we observed induction of MCP-2 and IL-6 by morphine. Morphine 60-68 interleukin 6 Homo sapiens 52-56 16624773-5 2006 RESULTS: In both groups plasma IL-6 and D-dimer levels showed significant increase at T(1), T(2) and T(3) in comparison with those at T(0), and their levels were significantly lower in morphine group than in ropivacaine group at T(1), T(2) and T(3). Morphine 185-193 interleukin 6 Homo sapiens 31-35 18990769-6 2008 Polymorphisms in TNF and IL-6 were significantly associated with pain severity (for TNF GG, 4.12; GA, 5.38; AA, 5.50; P = 0.04) and with morphine equivalent daily dose (IL-6 GG, 69.61; GC, 73.17; CC, 181.67; P = 0.004), respectively. Morphine 137-145 interleukin 6 Homo sapiens 25-29 19116667-5 2008 Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine-induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent. Morphine 84-92 interleukin 6 Homo sapiens 119-123 18349186-0 2008 The mu opioid receptor mediates morphine-induced tumor necrosis factor and interleukin-6 inhibition in toll-like receptor 2-stimulated monocytes. Morphine 32-40 interleukin 6 Homo sapiens 75-88 18349186-8 2008 Mu opioid receptor activation specifically mediated this morphine-induced TNF and IL-6 inhibition in monocytes. Morphine 57-65 interleukin 6 Homo sapiens 82-86 18349186-12 2008 CONCLUSIONS: The mu opioid receptor mediates morphine-induced TNF and IL-6 inhibition in PGN-stimulated monocytes, but not in PBMCs. Morphine 45-53 interleukin 6 Homo sapiens 70-74 19116667-7 2008 Similarly, chelating intracellular calcium ([Ca(2+)](i)) blocked Tat+/-morphine-evoked MCP-1 and IL-6 release, while artificially increasing the concentration of extracellular Ca(2+) reversed this effect. Morphine 71-79 interleukin 6 Homo sapiens 97-101 17513621-7 2007 The increase in serum IL-6 levels was significantly attenuated in the morphine group compared to the fentanyl group at 3 and 24 h post-CPB (P < 0.05). Morphine 70-78 interleukin 6 Homo sapiens 22-26 17513621-10 2007 CONCLUSIONS: Compared with fentanyl, the administration of morphine as part of balanced anesthetic technique suppressed several components the inflammatory response (IL-6, CD 11b, CD 18, postoperative hyperthermia) to cardiac surgery and CPB. Morphine 59-67 interleukin 6 Homo sapiens 166-170 16624773-6 2006 CONCLUSION: Epidural morphine can lower plasma IL-6 and D-dimer levels and correct blood hypercoagulability in patients undergoing total hip replacement. Morphine 21-29 interleukin 6 Homo sapiens 47-51 14975222-0 2004 Effects of morphine and fentanyl on tumor necrosis factor-alpha and interleukin-6 concentrations in human whole blood in vitro. Morphine 11-19 interleukin 6 Homo sapiens 68-81 9346391-10 1997 Neutralizing antibody to IL-6 inhibited the effect of morphine on RMIC. Morphine 54-62 interleukin 6 Homo sapiens 25-29 11289091-0 2001 Plasma levels of interleukin-6 and interleukin-10 are affected by ketorolac as an adjunct to patient-controlled morphine after abdominal hysterectomy. Morphine 112-120 interleukin 6 Homo sapiens 17-30 11289091-2 2001 Therefore, the purpose of this study was to determine differences between morphine patient-controlled analgesia and a combination of morphine and ketorolac in interleukin-6 and interleukin-10 responses, and in analgesia and morphine-related side effects. Morphine 74-82 interleukin 6 Homo sapiens 159-172 11289091-2 2001 Therefore, the purpose of this study was to determine differences between morphine patient-controlled analgesia and a combination of morphine and ketorolac in interleukin-6 and interleukin-10 responses, and in analgesia and morphine-related side effects. Morphine 133-141 interleukin 6 Homo sapiens 159-172 11289091-2 2001 Therefore, the purpose of this study was to determine differences between morphine patient-controlled analgesia and a combination of morphine and ketorolac in interleukin-6 and interleukin-10 responses, and in analgesia and morphine-related side effects. Morphine 133-141 interleukin 6 Homo sapiens 159-172 9571161-5 1998 Our studies show that morphine differentially modulates lipopolysaccharide (LPS) induced expression of IL-6 and TNF-alpha. Morphine 22-30 interleukin 6 Homo sapiens 103-107 9571161-6 1998 Nanomolar concentrations of morphine synergize with LPS and augment the secretion of both IL-6 and TNF-alpha. Morphine 28-36 interleukin 6 Homo sapiens 90-94 9571161-7 1998 However, at micromolar concentrations morphine inhibits LPS induced synthesis of IL-6 and TNF-alpha. Morphine 38-46 interleukin 6 Homo sapiens 81-85 9469525-13 1997 morphine reduced cortisol and IL-6 levels in the early hours after surgery. Morphine 0-8 interleukin 6 Homo sapiens 30-34 34774714-6 2022 Chronic morphine treatments for 7 days reduced the protein expression of MKP-1 and MKP-3 in the spinal cord and increased the phosphorylation of p38, ERK1/2 and the level of proinflammatory mediator, such as IL-1beta, IL-6 and TNF-alpha. Morphine 8-16 interleukin 6 Homo sapiens 218-222 26445552-12 2015 IL-6 -174G/C gene polymorphism is associated with a significant morphine equivalent daily dose (IL-6 GG, 69.61; GC, 73.17; CC, 181.67; P=0.004). Morphine 64-72 interleukin 6 Homo sapiens 0-4 32076422-5 2020 Morphine-exposure of RM-PBMCs infected with SHIVs 4NF-kappaB, 3NF-kappaB, and AD8EO altered cellular transcript levels of monocyte chemoattractant protein 1, interleukin 6, interleukin 1beta, and Tumor Necrosis Factor alpha. Morphine 0-8 interleukin 6 Homo sapiens 158-171 31626971-9 2020 Paradoxically, morphine increased the concentration of interleukin-6, granzyme A, and granzyme B in cell supernatants. Morphine 15-23 interleukin 6 Homo sapiens 55-68 31626971-10 2020 Pretreatment of NK cells with TAK-242 prevented the morphine-induced increase in interleukin-6, whereas pretreatment with naloxone inhibited the morphine-induced increase in granzymes A and B. Morphine 52-60 interleukin 6 Homo sapiens 81-94 31433352-8 2019 Statistically significant increases in IL-6 concentrations were induced by morphine only; NK cell activity was suppressed with morphine, but maintained with oxycodone and epidural analgesia.Gene expression profiles suggest that at 2 h post-incision morphine appeared to be immunosuppressive as compared to oxycodone and non-opioid control analgesia. Morphine 75-83 interleukin 6 Homo sapiens 39-43 31513981-9 2019 Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). Morphine 61-69 interleukin 6 Homo sapiens 7-11 31513981-9 2019 Plasma IL-6 levels were significantly associated with plasma morphine levels (P = 0.005) and urinary morphine-positive (+) results (P = 0.04), and significantly associated with poor compliance (P = 0.009) and early dropout from MMT (P = 0.001). Morphine 101-109 interleukin 6 Homo sapiens 7-11 29115971-7 2017 However, local anaesthetics alone or in combination with morphine and/or MgSO4 reduced cell viability and increased the gene expression of IL-1beta, IL-6 or TNF-alpha. Morphine 57-65 interleukin 6 Homo sapiens 149-153 31083166-4 2019 Spinal and IV morphine substantially increased IL-6 production, whereas epidural morphine hindered IL-10 and GM-CSF production. Morphine 14-22 interleukin 6 Homo sapiens 47-51 28697991-10 2017 In the morphine abuser, a decrease in pain threshold, an increase in IL-6 and a decrease in IL-10 levels were evident compared with non-abuser subjects. Morphine 7-15 interleukin 6 Homo sapiens 69-73 26985948-9 2016 Presence of the IL-6 -174G/C SNP is significantly correlated with morphine equivalent daily dose. Morphine 66-74 interleukin 6 Homo sapiens 16-20 26445552-12 2015 IL-6 -174G/C gene polymorphism is associated with a significant morphine equivalent daily dose (IL-6 GG, 69.61; GC, 73.17; CC, 181.67; P=0.004). Morphine 64-72 interleukin 6 Homo sapiens 96-100