PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15836969-3	2005	We report that administration of a neutral dose of IL-1beta abolished morphine analgesia in mice, whereas acute or chronic blockade of IL-1 signaling by various IL-1 blockers (IL-1 receptor antagonist (IL-1ra), alpha-melanocyte-stimulating hormone, or IL-1 tri-peptide antagonist) significantly prolonged and potentiated morphine analgesia.	Morphine	70-78	interleukin 1 complex	Mus musculus	51-55	
15836969-4	2005	Morphine-induced analgesia was also extended in strains of mice genetically impaired in IL-1 signaling (mice with transgenic over-expression of IL-1 receptor antagonist, deletion of the IL-1 receptor type I, or deletion of the IL-1 receptor accessory protein).	Morphine	0-8	interleukin 1 complex	Mus musculus	88-92	
15836969-4	2005	Morphine-induced analgesia was also extended in strains of mice genetically impaired in IL-1 signaling (mice with transgenic over-expression of IL-1 receptor antagonist, deletion of the IL-1 receptor type I, or deletion of the IL-1 receptor accessory protein).	Morphine	0-8	interleukin 1 complex	Mus musculus	144-148	
15836969-6	2005	Indeed, genetic or pharmacological blockade of IL-1 signaling prevented the development of tolerance following repeated morphine administration.	Morphine	120-128	interleukin 1 complex	Mus musculus	47-51	
15836969-7	2005	Moreover, acute administration of IL-1ra in wild type mice, either immediately following the cessation of acute morphine analgesia, or following the development of chronic morphine tolerance, re-instated the analgesia, suggesting that blockade of the IL-1 system unmasks the analgesic effect of morphine.	Morphine	112-120	interleukin 1 complex	Mus musculus	34-38	
15836969-7	2005	Moreover, acute administration of IL-1ra in wild type mice, either immediately following the cessation of acute morphine analgesia, or following the development of chronic morphine tolerance, re-instated the analgesia, suggesting that blockade of the IL-1 system unmasks the analgesic effect of morphine.	Morphine	172-180	interleukin 1 complex	Mus musculus	34-38	
15836969-7	2005	Moreover, acute administration of IL-1ra in wild type mice, either immediately following the cessation of acute morphine analgesia, or following the development of chronic morphine tolerance, re-instated the analgesia, suggesting that blockade of the IL-1 system unmasks the analgesic effect of morphine.	Morphine	172-180	interleukin 1 complex	Mus musculus	34-38	
15836969-8	2005	These findings suggest that morphine produces an IL-1-mediated homeostatic response, which serves to limit the duration and extent of morphine analgesia and which underlies the development of tolerance.	Morphine	28-36	interleukin 1 complex	Mus musculus	49-53	
15836969-8	2005	These findings suggest that morphine produces an IL-1-mediated homeostatic response, which serves to limit the duration and extent of morphine analgesia and which underlies the development of tolerance.	Morphine	134-142	interleukin 1 complex	Mus musculus	49-53	
1652466-0	1991	[3H]morphine binding is enhanced by IL-1-stimulated thymocyte proliferation.	Morphine	4-12	interleukin 1 complex	Mus musculus	36-40	
10447210-6	1999	The IL-1-induced behaviors were suppressed by intraperitoneal morphine, indicating that they are nociceptive responses.	Morphine	62-70	interleukin 1 complex	Mus musculus	4-8	
9795212-3	1998	In contrast, morphine reduction of splenic and thymic cell number and mitogen-induced proliferation were unaffected in MOR-KO mice, as was morphine inhibition of IL-1 and IL-6 secretion by macrophages.	Morphine	139-147	interleukin 1 complex	Mus musculus	162-166	
9259765-2	1997	In the present study, we investigated the mechanism by which morphine inhibits phytohemagglutinin (PHA)/interleukin-1 (IL-1)-induced thymocyte proliferation.	Morphine	61-69	interleukin 1 complex	Mus musculus	119-123	
8237606-7	1993	Addition of normal splenic macrophages to in vitro cultures restored immune responses, as did IL-1, IL-6 and IFN-gamma, suggesting that morphine-induced immunosuppression is due to a deficit in macrophage function.	Morphine	136-144	interleukin 1 complex	Mus musculus	94-98