PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25228763-5 2014 Here, we resolve this issue by showing that a plasma membrane chloride channel, encoded by ClC-a, is exclusively expressed in the stellate cell and is required for Drosophila kinin-mediated induction of diuresis and chloride shunt conductance, evidenced by chloride ion movement through the stellate cells, leading to depolarization of the transepithelial potential. Chlorides 62-70 Leucokinin Drosophila melanogaster 175-180 25228763-5 2014 Here, we resolve this issue by showing that a plasma membrane chloride channel, encoded by ClC-a, is exclusively expressed in the stellate cell and is required for Drosophila kinin-mediated induction of diuresis and chloride shunt conductance, evidenced by chloride ion movement through the stellate cells, leading to depolarization of the transepithelial potential. Chlorides 216-224 Leucokinin Drosophila melanogaster 175-180 25228763-8 2014 Therefore, the diuretic action of kinin in Drosophila can be explained by an increase in ClC-a-mediated chloride conductance, over and above a resting fluid transport level that relies on other (ClC-a-independent) mechanisms or routes. Chlorides 104-112 Leucokinin Drosophila melanogaster 34-39 8786336-7 1996 Taken together, these results show that leucokinin acts through intracellular Ca2+, independently of cyclic AMP or cyclic GMP, to raise the chloride permeability of the epithelium. Chlorides 140-148 Leucokinin Drosophila melanogaster 40-50 31913700-8 2020 Drosophila kinin decreased transepithelial potential and increased chloride permeability, and stimulated fluid secretion in both control and adult mesh knockdown tubules, but had no effect on 4 kDa dextran flux. Chlorides 67-75 Leucokinin Drosophila melanogaster 11-16 23445619-3 2013 Two such agents are the biogenic amine tyramine (TA) and the peptide drosokinin (DK), both of which act on the stellate cells of the tubule to increase transepithelial chloride conductance. Chlorides 168-176 Leucokinin Drosophila melanogaster 69-79 23446525-2 2013 In Drosophila, both Drosophila kinin and tyramine act on the Malpighian (renal) tubule stellate cell to activate chloride shunt conductance, and so increase the fluid production rate. Chlorides 113-121 Leucokinin Drosophila melanogaster 31-36 23446525-7 2013 Therefore, tyramine and Drosophila kinin signals converge on phospholipase C, and thence on intracellular calcium; and both act to increase chloride shunt conductance by signalling through itpr. Chlorides 140-148 Leucokinin Drosophila melanogaster 35-40