PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28779175-0	2017	CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.	Chlorides	16-24	NLR family pyrin domain containing 3	Homo sapiens	80-85	
31646445-3	2020	Accumulating investigations imply that chloride efflux-dependent ASC speck oligomerization and potassium efflux-dependent activation of caspase-1 are the two relatively independent, but indispensable events for NLRP3 inflammasome activation.	Chlorides	39-47	NLR family pyrin domain containing 3	Homo sapiens	211-216	
30232264-0	2018	Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.	Chlorides	0-8	NLR family pyrin domain containing 3	Homo sapiens	27-32	
28779175-5	2017	Mitochondrial ROS then induces the translocation of CLICs to the plasma membrane for the induction of chloride efflux to promote NEK7-NLRP3 interaction, inflammasome assembly, caspase-1 activation, and IL-1beta secretion.	Chlorides	102-110	NLR family pyrin domain containing 3	Homo sapiens	134-139	
28779175-6	2017	Thus, our results identify CLICs-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear.	Chlorides	43-51	NLR family pyrin domain containing 3	Homo sapiens	107-112	
28779175-6	2017	Thus, our results identify CLICs-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear.	Chlorides	43-51	NLR family pyrin domain containing 3	Homo sapiens	128-133	
35438288-3	2022	Mefenamic acid which belongs to fenamate group inhibits the NLRP3 inflammasome by inhibiting efflux of chloride ions and influx of calcium ions through blocking VRAC and TRPM2 respectively.	Chlorides	103-111	NLR family pyrin domain containing 3	Homo sapiens	60-65	
35171697-6	2022	Although the precise mechanisms of NLRP3 activation and regulation by these diverse agonists remain unclear, multiple reports indicate that all NLRP3 agonists ultimately lead to a drop in intracellular concentration of potassium (K+ efflux) and chloride (Cl- efflux).	Chlorides	245-253	NLR family pyrin domain containing 3	Homo sapiens	35-40	
35171697-6	2022	Although the precise mechanisms of NLRP3 activation and regulation by these diverse agonists remain unclear, multiple reports indicate that all NLRP3 agonists ultimately lead to a drop in intracellular concentration of potassium (K+ efflux) and chloride (Cl- efflux).	Chlorides	245-253	NLR family pyrin domain containing 3	Homo sapiens	144-149	
33677475-6	2021	In addition, the volume-sensitive chloride current of OA chondrocytes decreased significantly with the increase of the expression levels of inflammation-related proteins caspase-1, caspase-3, and NLRP3.	Chlorides	34-42	NLR family pyrin domain containing 3	Homo sapiens	196-201