PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33540760-6 2021 Susceptibility of patient samples for PTC596 in combination with S63845 or trametinib was significant for the majority of adverse risk primary and secondary AML with minimal efficacy in favorable risk AML, and correlated significantly with CD34 positivity of the samples. S63845 65-71 CD34 molecule Homo sapiens 240-244 33540760-8 2021 CONCLUSIONS: The combination of PTC596 and S63845 may be an effective treatment in CD34+ adverse risk AML with elevated MN1 gene expression and MCL1 protein levels, while PTC596 and trametinib may be more effective in CD34+ adverse risk AML with elevated BMI1 gene expression and MEK protein levels. S63845 43-49 CD34 molecule Homo sapiens 83-87