PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10622277-3	1999	XOR is an enzyme involved in purine metabolism, converting ATP metabolites hypoxanthine and xanthine to uric acid.	Xanthine	79-87	xanthine dehydrogenase	Rattus norvegicus	0-3	
15971422-2	2005	Nitrotyrosine is formed by nitration of tyrosine by reactive nitrogen species such as peroxynitrite, the formation of which may be enhanced by xanthine oxidoreductase (XOR), since it can generate nitric oxide from nitrite/nitrate, and superoxide during xanthine metabolism.	Xanthine	143-151	xanthine dehydrogenase	Rattus norvegicus	168-171	
11246119-5	2001	Incubation of cytosolic fraction with xanthine oxidoreductase (XDh+XO) (XOR) cosubstrates (e.g. NAD+, hypoxanthine, xanthine, caffeine, theobromine, theophylline or 1,7-dimethylxanthine) significantly enhanced the biotransformation of ethanol to acetaldehyde.	Xanthine	38-46	xanthine dehydrogenase	Rattus norvegicus	63-66	
11246119-5	2001	Incubation of cytosolic fraction with xanthine oxidoreductase (XDh+XO) (XOR) cosubstrates (e.g. NAD+, hypoxanthine, xanthine, caffeine, theobromine, theophylline or 1,7-dimethylxanthine) significantly enhanced the biotransformation of ethanol to acetaldehyde.	Xanthine	38-46	xanthine dehydrogenase	Rattus norvegicus	72-75	
18375259-3	2008	With the supply of molecular oxygen upon reperfusion of ischemic tissues, xanthine oxidoreductase (XOR) metabolizes xanthine and hypoxanthine to uric acid and free radicals are generated.	Xanthine	74-82	xanthine dehydrogenase	Rattus norvegicus	99-102	
17440754-6	2007	It was confirmed that, for the reducing substrate xanthine, rat liver XD is also a better O2*- source than XO.	Xanthine	50-58	xanthine dehydrogenase	Rattus norvegicus	70-72	
9288448-10	1997	Ischemia-evoked increases in xanthine concentration were attenuated by inhibition of adenosine deaminase or xanthine oxidase/xanthine dehydrogenase.	Xanthine	29-37	xanthine dehydrogenase	Rattus norvegicus	125-147	
9822451-4	1998	Xanthine oxidoreductase (XOR) oxidizes ATP metabolites hypoxanthine and xanthine to urate.	Xanthine	59-67	xanthine dehydrogenase	Rattus norvegicus	0-23	
9822451-4	1998	Xanthine oxidoreductase (XOR) oxidizes ATP metabolites hypoxanthine and xanthine to urate.	Xanthine	59-67	xanthine dehydrogenase	Rattus norvegicus	25-28	
33132325-8	2020	Furthermore, dotinurad, a URAT1 inhibitor, increased renal clearance of xanthine in rats treated with topiroxostat to inhibit XOR.	Xanthine	72-80	xanthine dehydrogenase	Rattus norvegicus	126-129	
8903395-11	1996	The finding of this low percentage of xanthine oxidase further stresses that the main function of xanthine oxidoreductase in the liver is not the production of superoxide anion radicals and/or hydrogen peroxide but rather the metabolism of xanthine to uric acid, which can act as a potent antioxidant.	Xanthine	38-46	xanthine dehydrogenase	Rattus norvegicus	98-121	
3162724-2	1988	The direct spectrophotometric measurement of the various forms of the xanthine-converting enzyme indicates that, in the fresh rat heart or after normoxic perfusion, there always is a basal level of 80% xanthine dehydrogenase and 20% of xanthine oxidase (15% irreversible and 5% reversible) that could contribute to the background production of free radicals.	Xanthine	70-78	xanthine dehydrogenase	Rattus norvegicus	202-224	
6952874-1	1981	The course of the reaction sequence hypoxanthine leads to xanthine leads to uric acid, catalysed by the NAD+-dependent activity of xanthine oxidoreductase, was investigated under conditions either of immediate oxidation of the NADH formed or of NADH accumulation.	Xanthine	40-48	xanthine dehydrogenase	Rattus norvegicus	131-154	
33132325-1	2020	Xanthine and hypoxanthine are intermediate metabolites of uric acid and a source of reactive oxidative species (ROS) by xanthine oxidoreductase (XOR), suggesting that facilitating their elimination is beneficial.	Xanthine	0-8	xanthine dehydrogenase	Rattus norvegicus	145-148	
21105859-1	2011	As a precedent study for elucidating the mechanism of possible urinary bladder carcinogenesis due to xanthine crystals induced by FYX-051, a xanthine oxidoreductase inhibitor, we have determined the experimental conditions suitable for the 52-week simultaneous treatment with citrate in F344 rats.	Xanthine	101-109	xanthine dehydrogenase	Rattus norvegicus	141-164	
24448833-0	2014	Xanthine crystals induced by topiroxostat, a xanthine oxidoreductase inhibitor, in rats, cause transitional cell tumors.	Xanthine	0-8	xanthine dehydrogenase	Rattus norvegicus	45-68	
21077683-1	2010	Two contradictory models have been proposed for the binding mode of the substrate xanthine to and its activation mechanism by xanthine oxidoreductase.	Xanthine	82-90	xanthine dehydrogenase	Rattus norvegicus	126-149