PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24626059-1 2014 The recreational drug 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") produces a neuro-inflammatory response in rats characterized by an increase in microglial activation and IL-1beta levels. N-Methyl-3,4-methylenedioxyamphetamine 22-55 interleukin 1 beta Rattus norvegicus 179-187 24626059-1 2014 The recreational drug 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") produces a neuro-inflammatory response in rats characterized by an increase in microglial activation and IL-1beta levels. N-Methyl-3,4-methylenedioxyamphetamine 57-61 interleukin 1 beta Rattus norvegicus 179-187 22114930-0 2011 Increased interleukin-1beta levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA. N-Methyl-3,4-methylenedioxyamphetamine 54-58 interleukin 1 beta Rattus norvegicus 10-27 22114930-0 2011 Increased interleukin-1beta levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA. N-Methyl-3,4-methylenedioxyamphetamine 130-134 interleukin 1 beta Rattus norvegicus 10-27 22114930-9 2011 RESULTS: Pretreatment with low dose MDMA attenuated both the 5-HT transporter loss and elevated IL-1beta levels induced by neurotoxic MDMA while producing an increase in IL-1ra levels. N-Methyl-3,4-methylenedioxyamphetamine 36-40 interleukin 1 beta Rattus norvegicus 96-104 22114930-10 2011 Low dose MDMA produced an increase in IL-1beta at 3 h and in IL-1ra at 96 h. sIL-1RI expression was also increased after low dose MDMA. N-Methyl-3,4-methylenedioxyamphetamine 9-13 interleukin 1 beta Rattus norvegicus 38-46 22114930-13 2011 Furthermore, IL-1beta (2.5 pg, intracortical) given 96 h before neurotoxic MDMA protected against the 5-HT neurotoxicity produced by the drug, thus mimicking preconditioning. N-Methyl-3,4-methylenedioxyamphetamine 75-79 interleukin 1 beta Rattus norvegicus 13-21 22114930-14 2011 CONCLUSIONS: These results suggest that IL-1beta plays an important role in the development of delayed preconditioning by low dose MDMA. N-Methyl-3,4-methylenedioxyamphetamine 131-135 interleukin 1 beta Rattus norvegicus 40-48 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 208-225 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 227-235 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 35-39 interleukin 1 beta Rattus norvegicus 208-225 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 35-39 interleukin 1 beta Rattus norvegicus 227-235 16165281-0 2005 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 48-65 16165281-0 2005 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 182-199 16165281-1 2005 3,4-Methylenedioxymethamphetamine (ecstasy) increases mature interleukin-1beta production in rat brain shortly after injection. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 61-78 16165281-1 2005 3,4-Methylenedioxymethamphetamine (ecstasy) increases mature interleukin-1beta production in rat brain shortly after injection. N-Methyl-3,4-methylenedioxyamphetamine 35-42 interleukin 1 beta Rattus norvegicus 61-78 16165281-4 2005 3,4-Methylenedioxymethamphetamine increased the immunoreactivity of pro-interleukin-1beta in frontal cortex, not in hypothalamus, 3 h and 6 h after administration. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 72-89 16165281-9 2005 These data indicate that 3,4-methylenedioxymethamphetamine alters, in a region-specific manner, the mechanisms which regulate interleukin-1beta production in the brain of Dark Agouti rats and suggest that the release of interleukin-1beta in hypothalamus may be regulated independently of caspase-1 activation. N-Methyl-3,4-methylenedioxyamphetamine 25-58 interleukin 1 beta Rattus norvegicus 126-143 16165281-9 2005 These data indicate that 3,4-methylenedioxymethamphetamine alters, in a region-specific manner, the mechanisms which regulate interleukin-1beta production in the brain of Dark Agouti rats and suggest that the release of interleukin-1beta in hypothalamus may be regulated independently of caspase-1 activation. N-Methyl-3,4-methylenedioxyamphetamine 25-58 interleukin 1 beta Rattus norvegicus 220-237 16165281-11 2005 of interleukin-1beta enhanced the 3,4-methylenedioxymethamphetamine-induced long-term loss of brain 5-HT parameters and immediate hyperthermia. N-Methyl-3,4-methylenedioxyamphetamine 34-67 interleukin 1 beta Rattus norvegicus 3-20 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 68-101 interleukin 1 beta Rattus norvegicus 38-55 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 38-55 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 238-255 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 38-55 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 238-255 15189347-0 2004 3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 44-61 15189347-4 2004 MDMA, given to rats housed at 22 degrees C, increased IL-1beta levels in hypothalamus and cortex from 1 to 6 h and [(3)H]-(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)3-isoquinolinecarboxamide) binding between 3 and 48 h. Increased immunoreactivity to OX-42 was also detected. N-Methyl-3,4-methylenedioxyamphetamine 0-4 interleukin 1 beta Rattus norvegicus 54-62 15189347-7 2004 When MDMA was given to rats housed at 4 degrees C, hyperthermia was abolished and the IL-1beta increase significantly reduced. N-Methyl-3,4-methylenedioxyamphetamine 5-9 interleukin 1 beta Rattus norvegicus 86-94 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 12-45 interleukin 1 beta Rattus norvegicus 136-154 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 12-45 interleukin 1 beta Rattus norvegicus 156-164 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 47-51 interleukin 1 beta Rattus norvegicus 136-154 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 47-51 interleukin 1 beta Rattus norvegicus 156-164 19777321-7 2010 Minocycline prevented the MDMA-induced increase in NFkappaB activation, IL-1beta release and microglial activation in the frontal cortex and prevented the 5-HT neurotoxicity 7 days later. N-Methyl-3,4-methylenedioxyamphetamine 26-30 interleukin 1 beta Rattus norvegicus 72-80 11334877-0 2001 Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin. N-Methyl-3,4-methylenedioxyamphetamine 0-29 interleukin 1 beta Rattus norvegicus 53-103 11334877-2 2001 We examined the effect of pretreatment with the selective serotonin reuptake inhibitor paroxetine, and the tryptophan hydroxylase inhibitor para-chlorophenylalanine on MDMA-induced suppression of interleukin-1beta and tumour necrosis factor (TNF)-alpha secretion following an in vivo lipopolysaccharide challenge. N-Methyl-3,4-methylenedioxyamphetamine 168-172 interleukin 1 beta Rattus norvegicus 196-213