PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17702902-6 2007 dose of the 5-hydroxytryptamine 1A (5-HT(1A)) antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide (WAY 100635) not only prevented MDMA-induced hypothermia, but resulted in the development of hyperthermia (mean temperature increase from baseline of 0.74 +/- 0.2 degrees C at 120 min). N-Methyl-3,4-methylenedioxyamphetamine 172-176 5-hydroxytryptamine receptor 1A Rattus norvegicus 36-43 23933156-4 2013 We sought to determine if the PVH and 5-HT1A receptors were also involved in mediating HPA responses to MDMA. N-Methyl-3,4-methylenedioxyamphetamine 104-108 5-hydroxytryptamine receptor 1A Rattus norvegicus 38-44 18534763-0 2008 When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists. N-Methyl-3,4-methylenedioxyamphetamine 49-82 5-hydroxytryptamine receptor 1A Rattus norvegicus 186-192 18534763-10 2008 Our results demonstrate that MDMA in a cold environment reduces core body temperature by inhibiting iBAT thermogenesis and tail artery vasoconstriction and suggest that mechanisms by which this occurs include the activation of 5-HT1A and dopamine D2 receptors. N-Methyl-3,4-methylenedioxyamphetamine 29-33 5-hydroxytryptamine receptor 1A Rattus norvegicus 227-233 17602794-0 2007 Short-term effects of 3,4-methylen-dioxy-metamphetamine (MDMA) on 5-HT(1A) receptors in the rat hippocampus. N-Methyl-3,4-methylenedioxyamphetamine 57-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 66-73 17602794-7 2007 In functional autoradiography, MDMA behaved either as a partial 5-HT(1A) antagonist in limbic areas or, added alone, as an agonist, increasing the coupling signal presumably through 5-HT release from synapses. N-Methyl-3,4-methylenedioxyamphetamine 31-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 64-71 17702902-12 2007 These results demonstrate that although hypothermia mediated by both MDMA and DPAT shares a common dependence on the activation of 5-HT(1A) receptors, the location of these receptors is different for each drug. N-Methyl-3,4-methylenedioxyamphetamine 69-73 5-hydroxytryptamine receptor 1A Rattus norvegicus 131-138 25050820-0 2014 Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia. N-Methyl-3,4-methylenedioxyamphetamine 92-96 5-hydroxytryptamine receptor 1A Rattus norvegicus 31-37 17702902-8 2007 To identify the location of 5-HT(1A) receptors responsible for hypothermia induced by MDMA, we first investigated the role of 5-HT(1A) receptors in the rostral raphe pallidus (rRP) in decreases in temperature evoked by the known 5-HT(1A) agonist 8-hydroxy-2-di-n-propylamino-tetralin (DPAT). N-Methyl-3,4-methylenedioxyamphetamine 86-90 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-35 17383105-0 2007 A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). N-Methyl-3,4-methylenedioxyamphetamine 71-104 5-hydroxytryptamine receptor 1A Rattus norvegicus 24-31 9300612-10 1997 WAY 100,135 had little effect on drug-appropriate responding; however, the discrimination of (+)-MDMA at 20 min was partly reduced by this 5-HT1A antagonist. N-Methyl-3,4-methylenedioxyamphetamine 93-101 5-hydroxytryptamine receptor 1A Rattus norvegicus 139-145 16817869-0 2006 MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation. N-Methyl-3,4-methylenedioxyamphetamine 0-4 5-hydroxytryptamine receptor 1A Rattus norvegicus 68-74 16483555-8 2006 Results indicated that early MDMA exposure caused a decrease in PKA activity and 5-HT content in the prefrontal cortex and hippocampus while increasing the efficacy of 5-HT1A receptors as measured by agonist-stimulated [35S]GTPgammaS binding. N-Methyl-3,4-methylenedioxyamphetamine 29-33 5-hydroxytryptamine receptor 1A Rattus norvegicus 168-174 16483555-10 2006 These data indicate that early MDMA exposure has long-term effects on the 5-HT and DA neurotransmitter systems that may be mediated, at least partially, by changes in 5-HT1A receptor sensitivity. N-Methyl-3,4-methylenedioxyamphetamine 31-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 167-173 15908091-0 2005 Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat. N-Methyl-3,4-methylenedioxyamphetamine 45-78 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-23 15908091-0 2005 Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat. N-Methyl-3,4-methylenedioxyamphetamine 80-84 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-23 11150898-0 2001 Effect of the repeated administration of (+/-)-3,4-methylenedioxymethamphetamine on the behavioral response of rats to the 5-HT1A receptor agonist (+/-)-8-hydroxy-(di-n-propylamino)tetralin. N-Methyl-3,4-methylenedioxyamphetamine 41-80 5-hydroxytryptamine receptor 1A Rattus norvegicus 123-129 11150898-1 2001 In this study, we examined the effect of the subcutaneous administration (twice daily for 4 consecutive days) of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg) or saline (1 ml/kg) on the response of rats to the behavioral effects of the 5-HT1A agonist (+/-)-8-hydroxy-(di-n-propylamino)tetralin (8-OH-DPAT) 30 days after the last saline or MDMA treatment. N-Methyl-3,4-methylenedioxyamphetamine 113-146 5-hydroxytryptamine receptor 1A Rattus norvegicus 241-247 10800921-1 2000 The aim of this study was to investigate if p-chloroamphetamine (PCA), which is neurotoxic to serotonin (5-HT) nerve terminals, was able to induce, like 3,4-methylenedioxymethamphetamine, a region-specific regulation of 5-HT1A receptor mRNA expression. N-Methyl-3,4-methylenedioxyamphetamine 153-186 5-hydroxytryptamine receptor 1A Rattus norvegicus 220-226 26856854-3 2016 Of particular interest are the 5-HT(1A) and 5-HT(1B) receptor subtypes since they have been implicated in several of the behaviors that have been shown to be impacted in ecstasy users and in animals exposed to MDMA. N-Methyl-3,4-methylenedioxyamphetamine 210-214 5-hydroxytryptamine receptor 1A Rattus norvegicus 31-38 9048755-1 1997 The present study examined the effects of repeated administration to rats of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on 5-hydroxytryptamine1A (5-HT1A) receptor density and mRNA expression in the hippocampus, frontal cortex, and brainstem. N-Methyl-3,4-methylenedioxyamphetamine 77-110 5-hydroxytryptamine receptor 1A Rattus norvegicus 132-153 9048755-1 1997 The present study examined the effects of repeated administration to rats of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on 5-hydroxytryptamine1A (5-HT1A) receptor density and mRNA expression in the hippocampus, frontal cortex, and brainstem. N-Methyl-3,4-methylenedioxyamphetamine 77-110 5-hydroxytryptamine receptor 1A Rattus norvegicus 155-161 9048755-1 1997 The present study examined the effects of repeated administration to rats of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on 5-hydroxytryptamine1A (5-HT1A) receptor density and mRNA expression in the hippocampus, frontal cortex, and brainstem. N-Methyl-3,4-methylenedioxyamphetamine 112-116 5-hydroxytryptamine receptor 1A Rattus norvegicus 132-153 9048755-1 1997 The present study examined the effects of repeated administration to rats of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on 5-hydroxytryptamine1A (5-HT1A) receptor density and mRNA expression in the hippocampus, frontal cortex, and brainstem. N-Methyl-3,4-methylenedioxyamphetamine 112-116 5-hydroxytryptamine receptor 1A Rattus norvegicus 155-161 9048755-1 1997 The present study examined the effects of repeated administration to rats of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on 5-hydroxytryptamine1A (5-HT1A) receptor density and mRNA expression in the hippocampus, frontal cortex, and brainstem. N-Methyl-3,4-methylenedioxyamphetamine 119-126 5-hydroxytryptamine receptor 1A Rattus norvegicus 132-153 9048755-1 1997 The present study examined the effects of repeated administration to rats of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") on 5-hydroxytryptamine1A (5-HT1A) receptor density and mRNA expression in the hippocampus, frontal cortex, and brainstem. N-Methyl-3,4-methylenedioxyamphetamine 119-126 5-hydroxytryptamine receptor 1A Rattus norvegicus 155-161 9048755-11 1997 In the brainstem, MDMA no longer reduced 5-HT1A receptor number in ADX rats, but a significant reduction was restored when ADX animals received the glucocorticoid treatment. N-Methyl-3,4-methylenedioxyamphetamine 18-22 5-hydroxytryptamine receptor 1A Rattus norvegicus 41-47 9048755-12 1997 The present data show that MDMA may affect 5-HT1A receptors in a regionally dependent manner, notably through a drug effect on corticosterone release, which attenuates 5-HT1A receptor gene transcription selectively in the hippocampus. N-Methyl-3,4-methylenedioxyamphetamine 27-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-49 9048755-12 1997 The present data show that MDMA may affect 5-HT1A receptors in a regionally dependent manner, notably through a drug effect on corticosterone release, which attenuates 5-HT1A receptor gene transcription selectively in the hippocampus. N-Methyl-3,4-methylenedioxyamphetamine 27-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 168-174 8566108-1 1995 The present study examined the short- and long-term effects of single and repeated administration of 3,4-methylenedioxy-methamphetamine (MDMA, "ecstasy") on somatodendritic and postsynaptic 5-HT1A receptors of the rat brain. N-Methyl-3,4-methylenedioxyamphetamine 101-135 5-hydroxytryptamine receptor 1A Rattus norvegicus 190-196 8566108-1 1995 The present study examined the short- and long-term effects of single and repeated administration of 3,4-methylenedioxy-methamphetamine (MDMA, "ecstasy") on somatodendritic and postsynaptic 5-HT1A receptors of the rat brain. N-Methyl-3,4-methylenedioxyamphetamine 137-141 5-hydroxytryptamine receptor 1A Rattus norvegicus 190-196 1361990-3 1992 Low doses of the 5-hydroxytryptamine1A (5-HT1A) antagonist NAN-190, the 5-HT2 antagonist pirenperone, and the dopamine antagonist haloperidol were able to somewhat attenuate the MDMA stimulus; however, none of these agents decreased MDMA-appropriate responding to less than 46%. N-Methyl-3,4-methylenedioxyamphetamine 178-182 5-hydroxytryptamine receptor 1A Rattus norvegicus 17-38 1361990-3 1992 Low doses of the 5-hydroxytryptamine1A (5-HT1A) antagonist NAN-190, the 5-HT2 antagonist pirenperone, and the dopamine antagonist haloperidol were able to somewhat attenuate the MDMA stimulus; however, none of these agents decreased MDMA-appropriate responding to less than 46%. N-Methyl-3,4-methylenedioxyamphetamine 178-182 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-46 1361990-3 1992 Low doses of the 5-hydroxytryptamine1A (5-HT1A) antagonist NAN-190, the 5-HT2 antagonist pirenperone, and the dopamine antagonist haloperidol were able to somewhat attenuate the MDMA stimulus; however, none of these agents decreased MDMA-appropriate responding to less than 46%. N-Methyl-3,4-methylenedioxyamphetamine 233-237 5-hydroxytryptamine receptor 1A Rattus norvegicus 17-38 1361990-3 1992 Low doses of the 5-hydroxytryptamine1A (5-HT1A) antagonist NAN-190, the 5-HT2 antagonist pirenperone, and the dopamine antagonist haloperidol were able to somewhat attenuate the MDMA stimulus; however, none of these agents decreased MDMA-appropriate responding to less than 46%. N-Methyl-3,4-methylenedioxyamphetamine 233-237 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-46 1982341-2 1990 In the present study, a blunted corticotropin and an enhanced prolactin response to the 5-HT1A agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH DPAT) was found in rats treated two weeks previously with a single dose of MDMA (2.0 or 20.0 mg/kg, sc). N-Methyl-3,4-methylenedioxyamphetamine 222-226 5-hydroxytryptamine receptor 1A Rattus norvegicus 88-94 8840347-7 1996 The data also support previous reports of contributions of 5-HT1A, D1 and D2 receptors to MDMA-stimulated locomotion. N-Methyl-3,4-methylenedioxyamphetamine 90-94 5-hydroxytryptamine receptor 1A Rattus norvegicus 59-65 8566108-4 1995 Multiple but not single MDMA administration significantly reduced 5-HT1A receptor density in the selected brain stem region. N-Methyl-3,4-methylenedioxyamphetamine 24-28 5-hydroxytryptamine receptor 1A Rattus norvegicus 66-72 1675609-7 1991 The novel 5-HT1A receptor antagonists, BMY 7378 and NAN-190, each abolished MDMA-evoked spontaneous tail-flicks. N-Methyl-3,4-methylenedioxyamphetamine 76-80 5-hydroxytryptamine receptor 1A Rattus norvegicus 10-16 1675609-9 1991 These data indicate that MDMA evokes spontaneous tail-flicks in the rat via a release of 5-HT which acts at 5-HT1A receptors. N-Methyl-3,4-methylenedioxyamphetamine 25-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 108-114 27264435-10 2016 The data suggest, however, that 5-HT1A agonists inhibit cue-induced drug-seeking following extinction of MDMA self-administration and might, therefore, be useful adjuncts to therapies to limit relapse to MDMA use. N-Methyl-3,4-methylenedioxyamphetamine 105-109 5-hydroxytryptamine receptor 1A Rattus norvegicus 32-38 27264435-10 2016 The data suggest, however, that 5-HT1A agonists inhibit cue-induced drug-seeking following extinction of MDMA self-administration and might, therefore, be useful adjuncts to therapies to limit relapse to MDMA use. N-Methyl-3,4-methylenedioxyamphetamine 204-208 5-hydroxytryptamine receptor 1A Rattus norvegicus 32-38