PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19703479-7 2010 The hyperlocomotion induced by methamphetamine and methylphenidate was lower, whereas that induced by MDMA was higher in orexin KO mice compared to WT mice. N-Methyl-3,4-methylenedioxyamphetamine 102-106 hypocretin Mus musculus 121-127 32653557-0 2021 Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice. N-Methyl-3,4-methylenedioxyamphetamine 40-73 hypocretin Mus musculus 77-83 32653557-7 2021 Interestingly, we found that MDMA induced a conditioned place preference in orexin KO mice, but not in wild type (WT) mice. N-Methyl-3,4-methylenedioxyamphetamine 29-33 hypocretin Mus musculus 76-82 32653557-8 2021 In addition, MDMA produced methylphenidate/methamphetamine-like discriminative stimulus effects in orexin KO mice, but not WT mice. N-Methyl-3,4-methylenedioxyamphetamine 13-17 hypocretin Mus musculus 99-105 32653557-13 2021 On the other hand, deficiencies in orexin may enhance the abuse liability of MDMA by changing a postsynaptic signal transduction accompanied by changes in discriminative stimulus effects themselves. N-Methyl-3,4-methylenedioxyamphetamine 77-81 hypocretin Mus musculus 35-41