PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14625694-1 2003 In the course of screening for inhibitors of transforming-growth factor-beta (TGF-beta) functions we found that conophylline, a vinca alkaloid, inhibited TGF-beta-induced apoptosis in rat hepatoma cells. conophylline 112-124 transforming growth factor, beta 1 Rattus norvegicus 78-86 14625694-1 2003 In the course of screening for inhibitors of transforming-growth factor-beta (TGF-beta) functions we found that conophylline, a vinca alkaloid, inhibited TGF-beta-induced apoptosis in rat hepatoma cells. conophylline 112-124 transforming growth factor, beta 1 Rattus norvegicus 154-162 14625694-2 2003 Because conophylline also inhibited TGF-b-induced promoter activity in mink lung cells, we studied the mechanism of the inhibition in this cell line. conophylline 8-20 transforming growth factor, beta 1 Rattus norvegicus 36-41 14625694-7 2003 Thus, our data suggest that inhibition of TGF-beta-induced promoter activity by conophylline can be attributed to its potency in modulating the interaction of downstream transcriptional factors via upregulation of c-Jun expression. conophylline 80-92 transforming growth factor, beta 1 Rattus norvegicus 42-50