PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24905513-7 2014 Prolactin response to stress in NAL-treated rats was blocked by l-DOPA administration. Levodopa 64-70 prolactin Rattus norvegicus 0-9 3448711-7 1987 The administration of a single injection of L-dopa led to decreases of plasma PRL and GH levels in both grafted and control rats, but while marked increases in hypothalamic and anterior pituitary contents of DA were shown in both groups, the hypothalamic content of NE was only increased in control animals. Levodopa 44-50 prolactin Rattus norvegicus 78-81 6933973-7 1980 Daily administration of 300 micrograms L-dopa led to a slight but insignificant increase of serum prolactin. Levodopa 39-45 prolactin Rattus norvegicus 98-107 7301038-5 1981 Injections of L-DOPA lowered prolactin in young but not in old rats, while apomorphine reduced prolactin levels in both groups. Levodopa 14-20 prolactin Rattus norvegicus 29-38 3585225-7 1987 Plasma prolactin concentrations were decreased by L-DOPA in both pituitary grafted and control rats. Levodopa 50-56 prolactin Rattus norvegicus 7-16 2858860-4 1985 Pretreatment with L-dopa (100 mg/kg body wt) completely blocked the PP-induced stimulation of prolactin release, indicating that antidopaminergic action of PP either at the hypothalamic or anterior pituitary level was responsible for its effects on the release of prolactin. Levodopa 18-24 prolactin Rattus norvegicus 94-103 2858860-4 1985 Pretreatment with L-dopa (100 mg/kg body wt) completely blocked the PP-induced stimulation of prolactin release, indicating that antidopaminergic action of PP either at the hypothalamic or anterior pituitary level was responsible for its effects on the release of prolactin. Levodopa 18-24 prolactin Rattus norvegicus 264-273 6745164-2 1984 Drugs that increase DA in hypophysial portal blood (amphetamine, methylphenidate and L-dopa) increased DA content, decreased PRL secretion, and had no effect on lysosomal enzyme activity. Levodopa 85-91 prolactin Rattus norvegicus 125-128 6745164-8 1984 Furthermore, pretreatment with bromocriptine and L-dopa blocked both the increase in serum PRL concentration and the decrease in anterior pituitary DA content induced by alpha-methyltyrosine and gamma-butyrolactone. Levodopa 49-55 prolactin Rattus norvegicus 91-94 6745164-9 1984 On the other hand, bromocriptine and L-dopa blocked the increase in serum PRL concentration but not the reduction in anterior pituitary DA content caused by reserpine, indicating that reserpine has a direct action on DA storage mechanisms in the anterior pituitary. Levodopa 37-43 prolactin Rattus norvegicus 74-77 6933996-5 1980 However, the two drugs known to decrease prolactin secretion (DOPA, CB 154) also caused some feminization. Levodopa 62-66 prolactin Rattus norvegicus 41-50 440533-0 1979 The effect of L-3,4-dihydroxyphenylalanine (L-dopa) on the prolactin response to sexual behavior in the male rat. Levodopa 14-42 prolactin Rattus norvegicus 59-68 440533-4 1979 Both the prolactin (Prl) response to ether and the Prl response to mating were suppressed by L-dopa. Levodopa 93-99 prolactin Rattus norvegicus 9-18 440533-4 1979 Both the prolactin (Prl) response to ether and the Prl response to mating were suppressed by L-dopa. Levodopa 93-99 prolactin Rattus norvegicus 20-23 440533-4 1979 Both the prolactin (Prl) response to ether and the Prl response to mating were suppressed by L-dopa. Levodopa 93-99 prolactin Rattus norvegicus 51-54 104513-5 1979 However, administration of L-DOPA resulted in a similar suppression of serum PRL in the SHR and in the normotensive controls. Levodopa 27-33 prolactin Rattus norvegicus 77-80 104513-7 1979 Observations of elevated basal PRL, exaggerated PRL in response to L-DOPA in SHR are consistent with normal pituitary responsiveness to dopamine suppression of PRL release, but defective hypothalamic metabolism of dopamine. Levodopa 67-73 prolactin Rattus norvegicus 48-51 104513-7 1979 Observations of elevated basal PRL, exaggerated PRL in response to L-DOPA in SHR are consistent with normal pituitary responsiveness to dopamine suppression of PRL release, but defective hypothalamic metabolism of dopamine. Levodopa 67-73 prolactin Rattus norvegicus 48-51 440533-0 1979 The effect of L-3,4-dihydroxyphenylalanine (L-dopa) on the prolactin response to sexual behavior in the male rat. Levodopa 44-50 prolactin Rattus norvegicus 59-68 614217-0 1977 Effect of L-dopa on Centchroman induced prolactin levels in female rats. Levodopa 10-16 prolactin Rattus norvegicus 40-49 744101-3 1978 Increases in plasma PRL induced by VIP were also significantly suppressed by L-dopa, a precursor of dopamine, whereas pilocarpine, a cholinergic agonist, diphenhydramine, a histamine antagonist, and cyproheptadine, an antiserotoninergic agent, did not affect the plasma PRL response to VIP. Levodopa 77-83 prolactin Rattus norvegicus 20-23 744101-3 1978 Increases in plasma PRL induced by VIP were also significantly suppressed by L-dopa, a precursor of dopamine, whereas pilocarpine, a cholinergic agonist, diphenhydramine, a histamine antagonist, and cyproheptadine, an antiserotoninergic agent, did not affect the plasma PRL response to VIP. Levodopa 77-83 prolactin Rattus norvegicus 270-273 1088127-2 1976 Increases in plasma prolactin concentrations caused by 5-HTP (1 mg/100 g body wt iv) were abolished by the concomitant administration of L-DOPA (2 mg/100 g body wt iv). Levodopa 137-143 prolactin Rattus norvegicus 20-29 560295-0 1977 L-Dopa inhibits prolactin secretion in proestrous rats. Levodopa 0-6 prolactin Rattus norvegicus 16-25 560295-2 1977 L-Dopa reduced serum prolactin concentrations within 1 h, whether administered just prior to, or during, the normal surge in serum hormone level. Levodopa 0-6 prolactin Rattus norvegicus 21-30 14035-5 1976 As already reported, L-DOPA and diethyldithiocarbamate markedly decreased plasma prolactin levels in rats. Levodopa 21-27 prolactin Rattus norvegicus 81-90 33823126-0 2021 Effects of L-dopa on expression of prolactin and synaptotagmin IV in 17-beta-estradiol-induced prolactinomas of ovariectomized hemiparkinsonian rats. Levodopa 11-17 prolactin Rattus norvegicus 35-44 1271349-0 1976 Prolactin release induced by suckling in lactating rats after L-DOPA treatment. Levodopa 62-68 prolactin Rattus norvegicus 0-9 1028957-2 1976 In contrast, the dopaminergic agonists apomorphine (APO), lisuride hydrogen meleate (LHM), D-amphetamine (AMPH), piribedil and L-dopa greatly lowered the high serum Prl concentrations in female rats induced by i.p. Levodopa 127-133 prolactin Rattus norvegicus 165-168 803259-7 1975 L-dopa administration significantly reduced serum prolactin values but had no significant effect on serum TSH. Levodopa 0-6 prolactin Rattus norvegicus 50-59 803259-9 1975 This suggest that L-dopa acts directly or indirectly on the pituitary prolactin cells to inhibit TRH stimulation of prolactin release, but does not influence the action of TRH on pituitary TSH cells. Levodopa 18-24 prolactin Rattus norvegicus 70-79 803259-9 1975 This suggest that L-dopa acts directly or indirectly on the pituitary prolactin cells to inhibit TRH stimulation of prolactin release, but does not influence the action of TRH on pituitary TSH cells. Levodopa 18-24 prolactin Rattus norvegicus 116-125 1241606-0 1975 L-Dopa effects on serum LH and prolactin in old and young female rats. Levodopa 0-6 prolactin Rattus norvegicus 31-40 1241606-1 1975 Serum LH and prolactin changes in response to an acute systemic L-dopa injection were measured in young (4-6 months) proestrous, estrous and 2nd day diestrous rats, and in aged (23-30 months) constant estrous and pseudopregnant (long diestrous) Long-Evans rats. Levodopa 64-70 prolactin Rattus norvegicus 13-22 1241606-6 1975 The reduction in serum prolactin following 3 mg of L-dopa was less in both the aged groups than in the young rats. Levodopa 51-57 prolactin Rattus norvegicus 23-32 1255091-0 1976 Prolactin inhibition test with L-dopa: decrease and restoration of plasma prolactin levels in the rat by a peripheral process. Levodopa 31-37 prolactin Rattus norvegicus 0-9 1255091-0 1976 Prolactin inhibition test with L-dopa: decrease and restoration of plasma prolactin levels in the rat by a peripheral process. Levodopa 31-37 prolactin Rattus norvegicus 74-83 1255091-1 1976 L-DOPA, within 30 min after administration, induced a highly significant decrease of plasma prolactin levels (phase 1) in a number of groups of rats, differing in age and/or endocrine status, apparently by direct inhibition of prolactin release from the pituitary. Levodopa 0-6 prolactin Rattus norvegicus 92-101 1255091-1 1976 L-DOPA, within 30 min after administration, induced a highly significant decrease of plasma prolactin levels (phase 1) in a number of groups of rats, differing in age and/or endocrine status, apparently by direct inhibition of prolactin release from the pituitary. Levodopa 0-6 prolactin Rattus norvegicus 227-236 1255091-2 1976 Three hours after administration of L-DOPA these low plasma prolactin concentrations in treated animals had increased (phase 2) and did not differ significantly from levels in control animals, indicating that the effect of L-DOPA on plasma prolactin levels is only of short duration. Levodopa 36-42 prolactin Rattus norvegicus 60-69 1255091-2 1976 Three hours after administration of L-DOPA these low plasma prolactin concentrations in treated animals had increased (phase 2) and did not differ significantly from levels in control animals, indicating that the effect of L-DOPA on plasma prolactin levels is only of short duration. Levodopa 223-229 prolactin Rattus norvegicus 240-249 1255091-8 1976 The results suggested another working mechanism of L-DOPA in decreasing plasma prolactin levels, namely by stimulating the uptake of this hormone in the periphery. Levodopa 51-57 prolactin Rattus norvegicus 79-88 1255091-9 1976 After the effect of L-DOPA had ceased, most of the prolactin from the periphery returned into the bloodstream, causing a rapid restoration of plasma prolactin levels without substantial release from the pituitary. Levodopa 20-26 prolactin Rattus norvegicus 51-60 1255091-9 1976 After the effect of L-DOPA had ceased, most of the prolactin from the periphery returned into the bloodstream, causing a rapid restoration of plasma prolactin levels without substantial release from the pituitary. Levodopa 20-26 prolactin Rattus norvegicus 149-158 1206326-10 1975 L-DOPA (5 and 10 mg) prevented the release of prolactin induced by suckling, but 1-25 and 2-5 mg L-DOPA had no effect. Levodopa 0-6 prolactin Rattus norvegicus 46-55 1109897-3 1975 Posterolateral deafferentation was as effective as complete deafferentation in preventing the stress-induced prolactin release, whereas anterior frontal deafferentation had only a small effect, L-Dopa (100 mg/kg body wt, ip) decreased prolactin titers in both control and deafferented animals, whereas reserpine (1 mg/kg body wt, ip) had the opposite effect. Levodopa 194-200 prolactin Rattus norvegicus 235-244 1109897-4 1975 Since both drugs inhibited prolactin release from pituitaries in vitro, the decrease of prolactin levels following L-dopa in vivo might have been caused not only by stimulation of PIF release but also at least partly by the direct effect of the drug on the pituitary. Levodopa 115-121 prolactin Rattus norvegicus 88-97 33823126-4 2021 Since both estradiol (E2) and L-dopa act as regulators of prolactin (PRL) secretion from the pituitary gland, we investigated their effect on the expression of PRL in prolactinomas that developed in ovariectomized hemiparkinsonian rats treated with 17b-E2. Levodopa 30-36 prolactin Rattus norvegicus 58-67