PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9361818-3	1997	When grown in CD medium (5 microM or 0 microM choline) CWSV-1 rat hepatocytes immortalized with SV40 large T-antigen underwent p53-independent apoptosis (terminal dUTP end-labeling of fragmented DNA; laddering of DNA in agarose gel).	Choline	46-53	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	127-130	
9111207-2	1997	CWSV-1 rat hepatocytes, in which p53 protein is inactivated by SV40 large T antigen, respond by inducing p53-independent apoptosis when acutely switched to medium containing low choline (16% apoptotic at 48 h in 5 microM choline) as compared with controls (1% apoptotic at 48 h in 70 microM choline).	Choline	221-228	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	33-36	
9111207-2	1997	CWSV-1 rat hepatocytes, in which p53 protein is inactivated by SV40 large T antigen, respond by inducing p53-independent apoptosis when acutely switched to medium containing low choline (16% apoptotic at 48 h in 5 microM choline) as compared with controls (1% apoptotic at 48 h in 70 microM choline).	Choline	221-228	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	33-36	
9361818-13	1997	Our results indicate that acute withdrawal of choline induces p53-independent programmed cell death in hepatocytes, whereas cells adapted to survive in low choline are resistant to this form of apoptosis, as well as to cell death induced by TGF beta 1.	Choline	46-53	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	62-65	
8950220-1	1996	Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing.	Choline	85-92	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	24-27	
8647350-1	1996	Immortalized CWSV-1 rat hepatocytes, in which p53 protein is inactivated by SV40 large T antigen, had increased numbers of cells with strand breaks in genomic DNA (terminal dUTP end labeling) when grown in 0 Micron choline (67-73% of cells) than when grown in 70 Micron choline (2-3% of cells).	Choline	215-222	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	46-49	
8647350-1	1996	Immortalized CWSV-1 rat hepatocytes, in which p53 protein is inactivated by SV40 large T antigen, had increased numbers of cells with strand breaks in genomic DNA (terminal dUTP end labeling) when grown in 0 Micron choline (67-73% of cells) than when grown in 70 Micron choline (2-3% of cells).	Choline	270-277	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	46-49	
8647350-8	1996	We conclude that choline deficiency kills CWSV-1 hepatocytes in culture by inducing apoptosis via what may be a p53-independent process, and that this process begins in viable cells before they detach from the culture dish.	Choline	17-24	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	112-115	
8453727-0	1993	p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male Fischer 344 rats.	Choline	56-63	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3	
2647288-1	1989	In rats maintained on a carcinogenic diet (choline deficient containing 0.1% ethionine), the levels of c-myc and p53 mRNAs increased by 4 wk after animals were placed on the diet.	Choline	43-50	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	113-116