PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30598629-0	2018	Variants in TPMT, ITPA, ABCC4 and ABCB1 Genes As Predictors of 6-mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia.	Mercaptopurine	63-79	ATP binding cassette subfamily B member 1	Homo sapiens	34-39	
25007187-1	2014	BACKGROUND: The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess whether these polymorphisms are predictors of treatment toxicity and/or MTX clearance.	Mercaptopurine	83-99	ATP binding cassette subfamily B member 1	Homo sapiens	163-168	
28710036-3	2017	Carriers of the ABCC4 934CC and ABCB1 1236TT genotypes received a lower percentage of the protocol-recommended starting dose of MTX (62.1 vs. 81.3% for 934CA carriers, p=0.001) and 6MP (73.1 vs. 87.7% for 1236CC/CT carriers; p=0.026), respectively.	Mercaptopurine	181-184	ATP binding cassette subfamily B member 1	Homo sapiens	32-37	
25007187-1	2014	BACKGROUND: The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess whether these polymorphisms are predictors of treatment toxicity and/or MTX clearance.	Mercaptopurine	83-99	ATP binding cassette subfamily B member 1	Homo sapiens	173-177	
15294454-2	2004	We have found that human MDR1 transfected murine L1210/VMDRC.06 leukemia cells exhibit relatively large amounts of Pgp and high levels of resistance to 6-mercaptopurine [6-MP] and other purine and pyrimidine nucleobase and nucleoside analogs.	Mercaptopurine	152-168	ATP binding cassette subfamily B member 1	Homo sapiens	25-29	
22866119-0	2011	Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells.	Mercaptopurine	63-79	ATP binding cassette subfamily B member 1	Homo sapiens	17-31	
22866119-6	2011	Taken together, these results suggest that the up-regulation of P-gp, which contributes to the decreased accumulation by increasing the efflux of 6-MP and its metabolites, underlies the mechanism of 6-MP resistance in K562 cells.	Mercaptopurine	146-150	ATP binding cassette subfamily B member 1	Homo sapiens	64-68