PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31442404-2 2019 Here we show that, in the mammalian small intestine, the expression of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies, including beta-hydroxybutyrate (betaOHB), distinguishes self-renewing Lgr5+ stem cells (ISCs) from differentiated cell types. 3-Hydroxybutyric Acid 214-234 NFS1 cysteine desulfurase Homo sapiens 292-296