PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25132361-0 2014 Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson"s disease: involvement of ERK1/2-Nrf2 signaling pathway. gastrodin 0-9 mitogen-activated protein kinase 3 Mus musculus 118-124 25132361-12 2014 SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. gastrodin 14-23 mitogen-activated protein kinase 3 Mus musculus 123-129 25132361-12 2014 SIGNIFICANCE: Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2-Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD. gastrodin 206-215 mitogen-activated protein kinase 3 Mus musculus 123-129 22922870-13 2012 Furthermore, the ERK1/2, p38 MAPK and Akt/GSK3beta signalling pathways were found to be involved in the effects of gastrodin. gastrodin 115-124 mitogen-activated protein kinase 3 Mus musculus 17-23 21833534-7 2012 The inhibitory effect of gastrodin on cardiac hypertrophy is mediated by ERK1/2 signaling and GATA-4 activation. gastrodin 25-34 mitogen-activated protein kinase 3 Mus musculus 73-79 21833534-8 2012 Further studies showed that gastrodin attenuated fibrosis and collagen synthesis through abrogating ERK1/2 signaling pathway. gastrodin 28-37 mitogen-activated protein kinase 3 Mus musculus 100-106 21833534-9 2012 Therefore, these findings indicated that gastrodin, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of ERK1/2 signaling. gastrodin 41-50 mitogen-activated protein kinase 3 Mus musculus 216-222