PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30816461-15	2019	From these findings, it was concluded that reduced neurotoxicity in striatal neurons following treatment with gastrodin may be attributed to its suppressive effects on the expression of p-ERK1/2, p-MEK1/2, BDNF and TrKB.	gastrodin	110-119	mitogen activated protein kinase 3	Rattus norvegicus	188-194	
27710899-0	2016	Proliferation-enhancing effects of gastrodin on RSC96 Schwann cells by regulating ERK1/2 and PI3K signaling pathways.	gastrodin	35-44	mitogen activated protein kinase 3	Rattus norvegicus	82-88	
24293261-9	2014	Increased levels of ERK1/2 phosphorylation and BDNF protein were also observed after GAS (20 mug/mL) treatment for 72 h. These results indicate that gastrodin possesses antidepressant effect.	gastrodin	149-158	mitogen activated protein kinase 3	Rattus norvegicus	20-26	
22982592-0	2012	Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway.	gastrodin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	114-120	
22982592-4	2012	Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation.	gastrodin	50-59	mitogen activated protein kinase 3	Rattus norvegicus	237-283	
22982592-4	2012	Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation.	gastrodin	50-59	mitogen activated protein kinase 3	Rattus norvegicus	285-291	
22982592-5	2012	Pharmacological blockade of ERK1/2 abrogation this action of gastrodin.	gastrodin	61-70	mitogen activated protein kinase 3	Rattus norvegicus	28-34	
22982592-6	2012	The ERK1/2 pathway may be involved in the neuroprotective effect of gastrodin against Abeta(1-42)-induced oxidative in primary cultured rat hippocampal neurons.	gastrodin	68-77	mitogen activated protein kinase 3	Rattus norvegicus	4-10	
22375417-2	2011	In present study, the effects of gastrodin on calcitonin gene-related peptide (CGRP) and phosphorylated extracellular signal-regulated kinase1/2 (pERK1/2) expression were observed in rat trigeminal ganglion (TG) after in vitro organ culture to explore the underlying intracellular mechanism of gastrodin on primary vascular-associated headache.	gastrodin	33-42	mitogen activated protein kinase 3	Rattus norvegicus	104-144	
22375417-7	2011	pERK1/2 level was examined by Western blotting after co-cultured with optimal concentration of gastrodin and effective specific ERK1/2 pathway inhibitors PD98059, U0126.	gastrodin	95-104	mitogen activated protein kinase 3	Rattus norvegicus	1-7	
22375417-9	2011	It suggests ERK1/2 signaling transduction pathway may be involved in gastrodin intracellular mechanism.	gastrodin	69-78	mitogen activated protein kinase 3	Rattus norvegicus	12-18	
22375417-10	2011	This study indicates gastrodin (5 and 10 mmol L(-1)) can remarkably reduce CGRP-ir (+) neuron, CGRP-mRNA and pERK1/2 expression level in cultured rat TG, with its actions similar to the effective concentration of sumatriptan succinate, flunarizine hydrochloride and specific ERK1/2 pathway blocker.	gastrodin	21-30	mitogen activated protein kinase 3	Rattus norvegicus	110-116