PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25212023-7 2014 The results showed that 4 of the 10 compounds could reduce the level of extracellular Abeta; they were cryptotanshinone, astragalosides, gastrodin and paeoniflorin, and their best concentration ranges were 0.5-5.0, 0.5-5.0, 5.0-50, 1.0-25 micromol x L(-1), respectively. gastrodin 137-146 amyloid beta precursor protein Homo sapiens 86-91 25212023-8 2014 Further study indicated that the 4 selected compounds were nontoxic to the cellular models and lowering intracellular Abeta were more effective compared with extracellular; of which astragalosides and gastrodin showed dose-dependent inhibition to the activities of beta and gamma-secretases, with the maximum inhibiting rates of 78.2% and 80.3%, respectively. gastrodin 201-210 amyloid beta precursor protein Homo sapiens 118-123 25212023-9 2014 In conclusion, cryptotanshinone, astragalosides, gastrodin and paeoniflorin could inhibit the expression and secretion of Abeta, and the underlying inhibiting mechanism of astragalosides and gastrodin were related with the reduction of the beta and gamma-secretase activities, respectively. gastrodin 49-58 amyloid beta precursor protein Homo sapiens 122-127 25212023-9 2014 In conclusion, cryptotanshinone, astragalosides, gastrodin and paeoniflorin could inhibit the expression and secretion of Abeta, and the underlying inhibiting mechanism of astragalosides and gastrodin were related with the reduction of the beta and gamma-secretase activities, respectively. gastrodin 191-200 amyloid beta precursor protein Homo sapiens 122-127