PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27624867-0 2017 Alternol, a natural compound, exerts an anti-tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways. Alternol 0-8 signal transducer and activator of transcription 3 Homo sapiens 92-97 27624867-6 2017 Moreover, alternol treatment inhibited signal transducer and activator of transcription-3 (STAT3) phosphorylation in 143B and MG63 human OS cells, as evaluated using a STAT3-dependent dual luciferase reporter system. Alternol 10-18 signal transducer and activator of transcription 3 Homo sapiens 39-89 27624867-6 2017 Moreover, alternol treatment inhibited signal transducer and activator of transcription-3 (STAT3) phosphorylation in 143B and MG63 human OS cells, as evaluated using a STAT3-dependent dual luciferase reporter system. Alternol 10-18 signal transducer and activator of transcription 3 Homo sapiens 91-96 27624867-6 2017 Moreover, alternol treatment inhibited signal transducer and activator of transcription-3 (STAT3) phosphorylation in 143B and MG63 human OS cells, as evaluated using a STAT3-dependent dual luciferase reporter system. Alternol 10-18 signal transducer and activator of transcription 3 Homo sapiens 168-173 27624867-11 2017 Immunohistochemistry revealed that alternol treatment resulted in down-regulation of phosph-STAT3 Tyr705 and up-regulation of cleaved caspase-3 and phosph-SAPK (Stress-activated protein kinases)/JNK expression. Alternol 35-43 signal transducer and activator of transcription 3 Homo sapiens 92-97 27624867-12 2017 Taken together, our results reveal that alternol suppresses cell proliferation, migration and induces apoptosis, cell cycle arrest by modulating of ROS-dependent MAPK and STAT3 signalling pathways in human OS cells. Alternol 40-48 signal transducer and activator of transcription 3 Homo sapiens 171-176