PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31015849-5 2019 Moreover, licochalcone A, alisol B, and hederagenin inhibited cell viability (p < 0.05), induced cell apoptosis (p < 0.01), reduced p-Akt levels, and increased cleaved-CASP3 (p < 0.05) and p53 expression levels in HepG2 cells. licochalcone A 10-24 AKT serine/threonine kinase 1 Homo sapiens 140-143 35237157-7 2022 Molecular docking analysis of the compounds to inflammation-associated targets revealed good binding abilities of quercetin, kaempferol, licochalcone A and liquiritin to NF-kappaB p65 and of quercetin and kaempferol to Akt1 or Caspase-3. licochalcone A 137-151 AKT serine/threonine kinase 1 Homo sapiens 219-223 33247550-7 2021 Mechanistically, we found that treatment with licochalcone A translationally suppressed survivin through inhibiting EGFR downstream kinases ERK1/2 and Akt. licochalcone A 46-60 AKT serine/threonine kinase 1 Homo sapiens 151-154 31941116-8 2020 Since both LicA-treatment and TrkB-knockdown decreased activation of protein kinase B in hypoxia, LicA exerts its inhibitory effect against hypoxic cell growth through inhibition of the TrkB-AKT axis. licochalcone A 98-102 AKT serine/threonine kinase 1 Homo sapiens 191-194 31239711-0 2019 Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma. licochalcone A 0-14 AKT serine/threonine kinase 1 Homo sapiens 96-99 31239711-14 2019 Conclusions: LCA might inhibit cell proliferation, migration, and invasion through regulating the PI3K/AKT pathway in OSCC, developing a potential chemotherapeutic agent for OSCC. licochalcone A 13-16 AKT serine/threonine kinase 1 Homo sapiens 103-106 34662660-0 2022 Activated PI3K/AKT/mTOR signal and suppressed autophagy participate in the protection offered by licochalcone A against Abeta25-35-induced injury in SH-SY5Y cells. licochalcone A 97-111 AKT serine/threonine kinase 1 Homo sapiens 15-18 29399197-0 2018 Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells. licochalcone A 0-14 AKT serine/threonine kinase 1 Homo sapiens 29-32 30347925-0 2018 [Effect of licochalcone A on autophagy in renal cell carcinoma via PI3K/Akt/mTOR signaling pathway]. licochalcone A 11-25 AKT serine/threonine kinase 1 Homo sapiens 72-75 29286170-0 2018 Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway. licochalcone A 0-14 AKT serine/threonine kinase 1 Homo sapiens 109-112 29399197-6 2018 The results from the present study indicate that Licochalcone A inhibits PI3K/Akt/mTOR activation, and promotes autophagy and apoptosis in MCF-7 cells. licochalcone A 49-63 AKT serine/threonine kinase 1 Homo sapiens 78-81 25981581-0 2015 Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. licochalcone A 0-14 AKT serine/threonine kinase 1 Homo sapiens 110-113 26311737-0 2015 Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells. licochalcone A 0-14 AKT serine/threonine kinase 1 Homo sapiens 46-49 25710724-8 2015 Western blotting analysis shows that LicoA suppresses sUV-induced phosphorylation of Akt/ mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinases (ERK)1/2/p90 ribosomal protein S6 kinase (RSK) in HaCaT cells. licochalcone A 37-42 AKT serine/threonine kinase 1 Homo sapiens 85-88 25149157-0 2014 Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression. licochalcone A 0-14 AKT serine/threonine kinase 1 Homo sapiens 102-105