PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22004718-0 2011 Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I). 7-azaindole dimer 42-54 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 70-74 22004718-2 2011 Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC(50)=1 nM) with 740-fold selectivity over PKA (47). 7-azaindole dimer 90-101 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 108-112 22004718-2 2011 Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC(50)=1 nM) with 740-fold selectivity over PKA (47). 7-azaindole dimer 90-101 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 150-154