PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23362262-6 2013 Using the mTOR inhibitor PP242, we found that TGFbeta-induced both early and sustained activation of TORC1 and TORC2 was necessary for deptor suppression. PP242 25-30 CREB regulated transcription coactivator 2 Homo sapiens 111-116 20686120-3 2010 To assess if the mammalian target of rapamycin within the TORC2 complex could be a better target in MM, we tested a new agent, pp242, which prevents activation of TORC2 as well as TORC1. PP242 127-132 CREB regulated transcription coactivator 2 Homo sapiens 58-63 20686120-3 2010 To assess if the mammalian target of rapamycin within the TORC2 complex could be a better target in MM, we tested a new agent, pp242, which prevents activation of TORC2 as well as TORC1. PP242 127-132 CREB regulated transcription coactivator 2 Homo sapiens 163-168 20686120-4 2010 Although comparable to rapamycin against phosphorylation of the TORC1 substrates p70S6kinase and 4E-BP-1, pp242 could also inhibit phosphorylation of AKT on serine 473, a TORC2 substrate, while rapamycin was ineffective. PP242 106-111 CREB regulated transcription coactivator 2 Homo sapiens 171-176 20072130-3 2010 We compared rapamycin with PP242, an inhibitor of the active site of mTOR in both TORC1 and TORC2 (hereafter referred to as TORC1/2), in models of acute leukemia harboring the Philadelphia chromosome (Ph) translocation. PP242 27-32 CREB regulated transcription coactivator 2 Homo sapiens 92-97 20072130-3 2010 We compared rapamycin with PP242, an inhibitor of the active site of mTOR in both TORC1 and TORC2 (hereafter referred to as TORC1/2), in models of acute leukemia harboring the Philadelphia chromosome (Ph) translocation. PP242 27-32 CREB regulated transcription coactivator 2 Homo sapiens 124-131