PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27180984-10 2016 Network target analysis and experimental validation in SY5Y and CT26 cells showed that the anti-tumor effect of nuciferine was mediated through inhibiting the PI3K-AKT signaling pathway and IL-1 levels in SY5Y and CT26 cells. nuciferine 112-122 interleukin 1 complex Mus musculus 190-194 27180984-11 2016 CONCLUSION: By using a TCM network pharmacology method, nuciferine is identified as an anti-tumor agent against human neuroblastoma and mouse colorectal cancer in vitro and in vivo, through inhibiting the PI3K-AKT signaling pathways and IL-1 levels. nuciferine 56-66 interleukin 1 complex Mus musculus 237-241