PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31115556-8 2019 Furthermore, puerarin mitigated H/R-induced oxidative stress as evidenced by the decrease in endogenous reactive oxygen species production, malondialdehyde content and NADPH oxidase 2 expression, and enhanced the antioxidative defense system as illustrated by the increase in superoxide dismutase activity, catalase and glutathione peroxidase levels. r 34-35 cytochrome b-245 beta chain Rattus norvegicus 168-183 21651898-6 2011 In addition, ZPT reversed the H/R-induced expression of NOX2 and p47(phox) phosphorylation indicating that ZPT directly protects cardiomyocytes from reperfusion injury by a mechanism that attenuates NADPH oxidase mediated intracellular oxidative stress. r 32-33 cytochrome b-245 beta chain Rattus norvegicus 56-60 29337194-5 2018 Consistent with the results in vivo, the H/R-treated H9c2 cells showed cellular injury (increase in apoptotic ratio), elevation in ROCK activity and nuclear p-MLC2v level, accompanied by up-regulation of NOX2 and H2O2 production; these effects were blocked in the presence of fasudil in a dose-dependent way. r 43-44 cytochrome b-245 beta chain Rattus norvegicus 204-208