PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34314383-0 2021 Curcumol may alleviate psoriasis-like inflammation by inhibiting keratinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling. curcumol 0-8 Janus kinase 1 Homo sapiens 129-133 34314383-5 2021 Curcumol inhibits activity of JAK1, resulting in the inhibition of STAT3, downregulation of cyclin D2, and cell cycle arrest in stimulated NHEK cells. curcumol 0-8 Janus kinase 1 Homo sapiens 30-34 34314383-6 2021 Together, our data show that curcumol reduces proliferation and inflammatory gene expression in stimulated keratinocytes by inhibiting the JAK1/STAT3 signaling, suggesting that it might serve as a potential therapeutic option for the treatment of psoriasis. curcumol 29-37 Janus kinase 1 Homo sapiens 139-143 32278762-8 2020 RESULTS: Curcumol reduced the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) via JAK1, JAK2, and Src pathways and inhibited hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis via mTOR/p70S6K/eIF4E and MAPK pathways. curcumol 9-17 Janus kinase 1 Homo sapiens 124-128