PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26711482-0 2016 Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells. Oxcarbazepine 64-77 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 25-29 26711482-2 2016 Auto-induction potentials of oxcarbazepine, its pharmacologically active metabolite 10-hydroxyoxcarbazepine and carbamazepine were evaluated by cytochrome P450 (CYP) 1A2, CYP2B6 and CYP3A4 mRNA levels and primary metabolic rates using human hepatocytes and HepaRG cells. Oxcarbazepine 29-42 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 171-177 26711482-4 2016 The fold change in mRNA levels for CYP2B6 was 11.5 (3.2-19.3), 7.0 (2.5-10.8) and 14.8 (3.1-29.1) for oxcarbazepine, 10-hydroxyoxcarbazepine and carbamazepine, respectively. Oxcarbazepine 102-115 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 35-41 26711482-9 2016 The 10-keto group instead of double bond at C10 position is evidently a determinant factor for limited auto-induction of P450 enzymes by oxcarbazepine. Oxcarbazepine 137-150 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 121-125