PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34122097-12 2021 HLA-DRB1*04:06 showed relatively specific high affinity with S-monohydroxy derivative of OXC. Oxcarbazepine 89-92 major histocompatibility complex, class II, DR beta 1 Homo sapiens 0-8 30599396-1 2019 PURPOSE: To determine genetic associations between oxcarbazepine (OXC)-induced cutaneous adverse drug reactions (cADRs) and human leukocyte antigen (HLA) variants in the Eastern Han Chinese population. Oxcarbazepine 51-64 major histocompatibility complex, class II, DR beta 1 Homo sapiens 149-152 30599396-1 2019 PURPOSE: To determine genetic associations between oxcarbazepine (OXC)-induced cutaneous adverse drug reactions (cADRs) and human leukocyte antigen (HLA) variants in the Eastern Han Chinese population. Oxcarbazepine 66-69 major histocompatibility complex, class II, DR beta 1 Homo sapiens 149-152 27666425-0 2016 HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption. Oxcarbazepine 48-61 major histocompatibility complex, class II, DR beta 1 Homo sapiens 16-20 27666425-7 2016 RESULTS: The HLA-B*40:02 and HLA-DRB1*04:03 alleles were significantly associated with OXC-induced MPE compared with the OXC-tolerant group (odds ratio [OR] 4.33, p = 0.018 and OR 14.64, p = 0.003, respectively) and the general Korean population (OR 4.04, p = 0.001 and OR 3.11, p = 0.019, respectively). Oxcarbazepine 87-90 major histocompatibility complex, class II, DR beta 1 Homo sapiens 29-37 27666425-7 2016 RESULTS: The HLA-B*40:02 and HLA-DRB1*04:03 alleles were significantly associated with OXC-induced MPE compared with the OXC-tolerant group (odds ratio [OR] 4.33, p = 0.018 and OR 14.64, p = 0.003, respectively) and the general Korean population (OR 4.04, p = 0.001 and OR 3.11, p = 0.019, respectively). Oxcarbazepine 121-124 major histocompatibility complex, class II, DR beta 1 Homo sapiens 29-37 27666425-10 2016 SIGNIFICANCE: This study is the first to demonstrate an association of HLA-B*40:02 and HLA-DRB1*04:03 with OXC hypersensitivity using a large cohort of patients with OXC-induced MPE. Oxcarbazepine 107-110 major histocompatibility complex, class II, DR beta 1 Homo sapiens 87-95 27666425-10 2016 SIGNIFICANCE: This study is the first to demonstrate an association of HLA-B*40:02 and HLA-DRB1*04:03 with OXC hypersensitivity using a large cohort of patients with OXC-induced MPE. Oxcarbazepine 166-169 major histocompatibility complex, class II, DR beta 1 Homo sapiens 87-95 34122097-13 2021 HLA-DRB1*04:06 is a specific risk allele for OXC-induced MPE in the Southern Han Chinese. Oxcarbazepine 45-48 major histocompatibility complex, class II, DR beta 1 Homo sapiens 0-8