PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6865996-4 1983 The relationship between O6-methylguanine and induced mutations in CHO cells is similar to that previously reported in CHO cells for O6-ethylguanine and mutations (Heflich et al., 1982) and indicates that alkylation-induced mutations at the HGPRT locus in CHO cells are primarily associated with O6-alkylguanine formation. cho 67-70 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 241-246 9701054-8 1997 When the CHO cells were given 10 repetitive 20 mM DEA/NO exposures (3 min each), HGPRT mutant frequency was 4.1 x control. cho 9-12 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 81-86 7410492-4 1980 The growth inhibitory effects of alanosine, or alanosine and guanine, on CHO cells are completely reverted by the addition of adenine to the culture medium, and the synergistic effect of guanine is not observed in mutants which lack the enzyme hypoxanthine-guanine phosphoribosyl transferase. cho 73-76 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 244-291 6807556-7 1982 Furthermore, the time-course for killing CHO cells deficient in HGPRTase was different from that in wild-type cells containing the enzyme. cho 41-44 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 64-72 7360155-13 1980 The rapid expression of mutations for both markers, particularly AAr, combined with the advantage that large inocula can be plated for selection of mutants, make this CHO strain an attractive system for the simultaneous measurement of mutations at the autosomal aprt and X-linked hprt loci. cho 167-170 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 280-284