PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19254961-6 2009 In CHO-677 cells deficient in HS biosynthesis, heparin enhanced FGF-2-induced phosphorylation of ERK1/2. cho 3-6 fibroblast growth factor 2 Cricetulus griseus 64-69 11473122-6 2001 They also inhibited 125I-FGF2 binding to FGFR1-overexpressing HSPG-bearing CHO cells and adult bovine aortic endothelial cells. cho 75-78 fibroblast growth factor 2 Cricetulus griseus 25-29 7592623-4 1995 FGF-2-dependent attachment of 32D-flg cells was prevented by inclusion of 10 micrograms/ml heparin in the incubation medium and was diminished when CHO mutants in glycosaminoglycan synthesis or wild-type CHO cells treated with heparinase were used, indicating that the attachment occurred through FGF-2 interactions with heparan sulfates on the CHO cells. cho 148-151 fibroblast growth factor 2 Cricetulus griseus 0-5 7592623-4 1995 FGF-2-dependent attachment of 32D-flg cells was prevented by inclusion of 10 micrograms/ml heparin in the incubation medium and was diminished when CHO mutants in glycosaminoglycan synthesis or wild-type CHO cells treated with heparinase were used, indicating that the attachment occurred through FGF-2 interactions with heparan sulfates on the CHO cells. cho 204-207 fibroblast growth factor 2 Cricetulus griseus 0-5 7592623-4 1995 FGF-2-dependent attachment of 32D-flg cells was prevented by inclusion of 10 micrograms/ml heparin in the incubation medium and was diminished when CHO mutants in glycosaminoglycan synthesis or wild-type CHO cells treated with heparinase were used, indicating that the attachment occurred through FGF-2 interactions with heparan sulfates on the CHO cells. cho 204-207 fibroblast growth factor 2 Cricetulus griseus 0-5 7592623-8 1995 We conclude that attachment is due to FGF-2 binding simultaneously to receptors on the 32D-flg cells and heparan sulfates on the CHO monolayers; thus, the FGF-2 acts as a bridge between receptor-expressing cells and heparan sulfate-bearing cells. cho 129-132 fibroblast growth factor 2 Cricetulus griseus 155-160 7592623-9 1995 In addition, induction of DNA synthesis in 32D-flg cells in response to FGF-2 was potentiated by the CHO-associated heparan sulfates to the same extent as by soluble heparin, indicating that this interaction has functional significance. cho 101-104 fibroblast growth factor 2 Cricetulus griseus 72-77