PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31006910-0	2019	Furanodienone overcomes temozolomide resistance in glioblastoma through the downregulation of CSPG4-Akt-ERK signalling by inhibiting EGR1-dependent transcription.	furanodienone	0-13	chondroitin sulfate proteoglycan 4	Homo sapiens	94-99	
31006910-4	2019	In this study, we found that furanodienone (FUR), a diene-type sesquiterpene isolated from the rhizomes of Rhizoma curcumae, exhibited a potential cytotoxic effect on temozolomide (TMZ)-resistant GBM cells in vitro by inhibiting CSPG4 and related signalling pathways.	furanodienone	29-42	chondroitin sulfate proteoglycan 4	Homo sapiens	229-234	
31006910-4	2019	In this study, we found that furanodienone (FUR), a diene-type sesquiterpene isolated from the rhizomes of Rhizoma curcumae, exhibited a potential cytotoxic effect on temozolomide (TMZ)-resistant GBM cells in vitro by inhibiting CSPG4 and related signalling pathways.	furanodienone	44-47	chondroitin sulfate proteoglycan 4	Homo sapiens	229-234	
31006910-5	2019	Studies investigating the mechanism demonstrated that FUR suppressed CSPG4-Akt-ERK signalling, inflammatory responses, and cytokine levels but activated caspase-dependent pathways and mitochondrial dysfunction.	furanodienone	54-57	chondroitin sulfate proteoglycan 4	Homo sapiens	69-74	
31006910-6	2019	Furthermore, an immunofluorescence assay and a dual-luciferase reporter assay revealed that inhibition of EGR1-mediated transcription might have contributed to the FUR-dependent blockade of CSPG4 signalling and glioma cell survival.	furanodienone	164-167	chondroitin sulfate proteoglycan 4	Homo sapiens	190-195	
31006910-7	2019	These results established a link between FUR-induced CSPG4 inhibition and the suppression of EGR1-dependent transcription.	furanodienone	41-44	chondroitin sulfate proteoglycan 4	Homo sapiens	53-58	
31006910-8	2019	Attenuation of ERK1/2 and cytokine signalling might have generated the EGR1-dependent negative feedback loop of the CSPG4 pathway during FUR-induced apoptosis.	furanodienone	137-140	chondroitin sulfate proteoglycan 4	Homo sapiens	116-121	
31006910-9	2019	These findings suggested that FUR could be a therapeutic candidate for the treatment of malignant glioma via targeting CSPG4 signalling.	furanodienone	30-33	chondroitin sulfate proteoglycan 4	Homo sapiens	119-124