PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22116286-0	2011	Inhibition of CYP3A4 and CYP2C9 by podophyllotoxin: implication for clinical drug-drug interactions.	Podophyllotoxin	35-50	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	25-31	
22116286-3	2011	Inhibition of CYP3A4, CYP2C9, CYP2C8, CYP2D6, CYP2E1 and CYP2A6 by PPT was investigated in the human liver microsomal system.	Podophyllotoxin	67-70	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28	
22116286-5	2011	The results showed that PPT strongly exhibited inhibitory effects on CYP3A4 and CYP2C9 in a concentration-dependent manner.	Podophyllotoxin	24-27	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	80-86	
22116286-7	2011	Inhibition kinetic analysis showed that PPT exhibited competitive inhibition towards CYP3A4 and CYP2C9 with Ki of 1.6 and 2.0 meu M, respectively.	Podophyllotoxin	40-43	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	96-102	
22116286-9	2011	Our experimental data indicate that potential drug-drug interaction (DDI) might exist when PPT is co-administered with the substrates which mainly undergo CYP3A4- or CYP2C9-mediated metabolism.	Podophyllotoxin	91-94	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	166-172	
16753237-1	2006	Biotransformation of deoxypodophyllotoxin to epipodophyllotoxin by three major human hepatic enzymes, CYP1A2, CYP2C9 and CYP3A4, heterologously expressed in E. coli DH5alpha, was investigated.	Podophyllotoxin	45-63	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	110-116