PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18048490-6	2008	Pretreatment with pregnenolone 16alpha-carbonitrile (PCN) and 1,4-bis-2-(3, 5-dichloropyridyloxy)-benzene (TCPOBOP) elevated CYP3A4 expression in double transgenic mice.	Pregnenolone Carbonitrile	18-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131	
15817670-5	2005	Pregnenolone 16alpha-carbonitrile markedly induced hepatic CYP3A4 expression, and the level was higher in females than males.	Pregnenolone Carbonitrile	0-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65	
10219967-9	1999	Induction of CYP3A4-dependent reporter gene expression and enhancement of the induction by the glucocorticoid receptor was also observed with pregnenolone-16alpha-carbonitrile (PCN), rifampicin, phenytoin, carbamazepine, phenylbutazone and phenobarbitone, all known in vivo inducers of CYP3A4 in man.	Pregnenolone Carbonitrile	142-175	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	13-19	
15180307-8	2004	Taken together, these results indicated that the inhibition of histone deacetylation was required to SXR-mediated increase in CYP3A4 proximal promoter region when rifampicin, or PCN was treated.	Pregnenolone Carbonitrile	178-181	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132	
11248085-1	2001	The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals.	Pregnenolone Carbonitrile	85-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-157	
11248085-1	2001	The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals.	Pregnenolone Carbonitrile	85-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	159-164	
11248085-1	2001	The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals.	Pregnenolone Carbonitrile	120-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-157	
11248085-1	2001	The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals.	Pregnenolone Carbonitrile	120-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	159-164	
11090943-8	2000	And finally, PXRs from different species are differentially activated by certain compounds such as rifampicin and pregnenolone 16alpha-carbonitrile (PCN) in a manner that correlates with species-specific induction of CYP3A gene expression.	Pregnenolone Carbonitrile	114-147	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	217-222	
11090943-8	2000	And finally, PXRs from different species are differentially activated by certain compounds such as rifampicin and pregnenolone 16alpha-carbonitrile (PCN) in a manner that correlates with species-specific induction of CYP3A gene expression.	Pregnenolone Carbonitrile	149-152	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	217-222	
10219967-9	1999	Induction of CYP3A4-dependent reporter gene expression and enhancement of the induction by the glucocorticoid receptor was also observed with pregnenolone-16alpha-carbonitrile (PCN), rifampicin, phenytoin, carbamazepine, phenylbutazone and phenobarbitone, all known in vivo inducers of CYP3A4 in man.	Pregnenolone Carbonitrile	177-180	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	13-19	
10219967-9	1999	Induction of CYP3A4-dependent reporter gene expression and enhancement of the induction by the glucocorticoid receptor was also observed with pregnenolone-16alpha-carbonitrile (PCN), rifampicin, phenytoin, carbamazepine, phenylbutazone and phenobarbitone, all known in vivo inducers of CYP3A4 in man.	Pregnenolone Carbonitrile	177-180	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	286-292	
8619627-5	1996	A putative CYP3A protein is expressed in PLHC-1 cells but its content was not altered by exposure of cultures to the prototypical mammalian CYP3A inducers dexamethasone (DEX), pregnenolone-16 alpha-carbonitrile (PCN), or rifampicin (RIF).	Pregnenolone Carbonitrile	176-210	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-16	
8700101-4	1996	When we transfected into cultured rat hepatocytes vectors containing 5"-flanking DNA from CYP3A23, CYP3A4, or CYP3A6 genes, we found that CAT activity was induced on treatment with dexamethasone or pregnenolone-16 alpha-carbonitrile only if consensus II sequences were included.	Pregnenolone Carbonitrile	198-232	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	99-105	
8619627-5	1996	A putative CYP3A protein is expressed in PLHC-1 cells but its content was not altered by exposure of cultures to the prototypical mammalian CYP3A inducers dexamethasone (DEX), pregnenolone-16 alpha-carbonitrile (PCN), or rifampicin (RIF).	Pregnenolone Carbonitrile	212-215	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-16