PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20101004-5 2010 It is noteworthy that dosing 12-week-old, asymptomatic hAPP mice over 7 days with pregnenolone-16alpha-carbonitrile to activate the nuclear receptor pregnane X receptor restores P-glycoprotein expression and transport activity in brain capillaries and significantly reduces brain Abeta levels compared with untreated control mice. Pregnenolone Carbonitrile 82-115 amyloid beta (A4) precursor protein Mus musculus 280-285