PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10462436-3 1999 Roles for three "orphan" nuclear receptor superfamily members, designated CAR, PXR, and PPAR, in respectively mediating the induction of hepatic P450s belonging to families CYP2, CYP3, and CYP4 in response to the prototypical inducers phenobarbital (CAR), pregnenolone 16alpha-carbonitrile and rifampicin (PXR), and clofibric acid (PPAR) have now been established. Pregnenolone Carbonitrile 256-289 nuclear receptor subfamily 1 group I member 2 Homo sapiens 79-82 11248085-1 2001 The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. Pregnenolone Carbonitrile 85-118 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-23 11248085-1 2001 The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. Pregnenolone Carbonitrile 85-118 nuclear receptor subfamily 1 group I member 2 Homo sapiens 25-28 12354121-8 2002 These mutants showed that this residue is important for the species specific activation of PXR by the ligand pregnenolone-16alpha-carbonitrile (PCN), while having a less pronounced role in receptor activation by rifampicin. Pregnenolone Carbonitrile 109-142 nuclear receptor subfamily 1 group I member 2 Homo sapiens 91-94 12354121-8 2002 These mutants showed that this residue is important for the species specific activation of PXR by the ligand pregnenolone-16alpha-carbonitrile (PCN), while having a less pronounced role in receptor activation by rifampicin. Pregnenolone Carbonitrile 144-147 nuclear receptor subfamily 1 group I member 2 Homo sapiens 91-94 11248085-1 2001 The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. Pregnenolone Carbonitrile 120-123 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-23 11248085-1 2001 The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. Pregnenolone Carbonitrile 120-123 nuclear receptor subfamily 1 group I member 2 Homo sapiens 25-28 10462436-3 1999 Roles for three "orphan" nuclear receptor superfamily members, designated CAR, PXR, and PPAR, in respectively mediating the induction of hepatic P450s belonging to families CYP2, CYP3, and CYP4 in response to the prototypical inducers phenobarbital (CAR), pregnenolone 16alpha-carbonitrile and rifampicin (PXR), and clofibric acid (PPAR) have now been established. Pregnenolone Carbonitrile 256-289 nuclear receptor subfamily 1 group I member 2 Homo sapiens 306-309 34447675-9 2021 Activation of PXR by pregnenolone 16alpha-carbonitrile increased AFB1-induced liver tumor incidence by up-regulating oncogenic KRAS to enhance interleukin (IL)-11:IL-11 receptor subunit alpha-1 (IL11RA-1)-mediated inflammation in an HBx transgenic model. Pregnenolone Carbonitrile 21-54 nuclear receptor subfamily 1 group I member 2 Homo sapiens 14-17 19147857-8 2009 To activate PXR, we used the PXR ligands, rifampicin, hyperforin, and pregnenolone-16alpha-carbonitrile (PCN), and measured abcb1 mRNA with quantitative polymerase chain reaction, P-glycoprotein expression with Western blotting, and P-glycoprotein transport activity with a calcein assay. Pregnenolone Carbonitrile 70-103 nuclear receptor subfamily 1 group I member 2 Homo sapiens 12-15 28624525-4 2017 Consistent with mammalian-like MDR/MXR regulated by PXR, the PCN-mediated modulation of hepatic Abcb4 and Cyp3a65 mRNA levels and MDR/MXR functional activity was attenuated by co-treatment with PCN and the mammalian PXR antagonist, ketoconazole (KTC). Pregnenolone Carbonitrile 61-64 nuclear receptor subfamily 1 group I member 2 Homo sapiens 52-55 22332017-4 2011 Nevertheless, pregnenolone-16alpha-carbonitrile (GR antagonist) and clotrimazole strongly and moderately decreased ABCC11 expression levels in Glucocortocoid Receptor-(GR-) and Pregnane X Receptor (PXR)-positive MCF7 cells but not in MDA-MB-231 cells (GR- and PXR-positive). Pregnenolone Carbonitrile 14-47 nuclear receptor subfamily 1 group I member 2 Homo sapiens 177-196 22332017-4 2011 Nevertheless, pregnenolone-16alpha-carbonitrile (GR antagonist) and clotrimazole strongly and moderately decreased ABCC11 expression levels in Glucocortocoid Receptor-(GR-) and Pregnane X Receptor (PXR)-positive MCF7 cells but not in MDA-MB-231 cells (GR- and PXR-positive). Pregnenolone Carbonitrile 14-47 nuclear receptor subfamily 1 group I member 2 Homo sapiens 198-201 22332017-4 2011 Nevertheless, pregnenolone-16alpha-carbonitrile (GR antagonist) and clotrimazole strongly and moderately decreased ABCC11 expression levels in Glucocortocoid Receptor-(GR-) and Pregnane X Receptor (PXR)-positive MCF7 cells but not in MDA-MB-231 cells (GR- and PXR-positive). Pregnenolone Carbonitrile 14-47 nuclear receptor subfamily 1 group I member 2 Homo sapiens 260-263 28624525-4 2017 Consistent with mammalian-like MDR/MXR regulated by PXR, the PCN-mediated modulation of hepatic Abcb4 and Cyp3a65 mRNA levels and MDR/MXR functional activity was attenuated by co-treatment with PCN and the mammalian PXR antagonist, ketoconazole (KTC). Pregnenolone Carbonitrile 61-64 nuclear receptor subfamily 1 group I member 2 Homo sapiens 216-219 28624525-4 2017 Consistent with mammalian-like MDR/MXR regulated by PXR, the PCN-mediated modulation of hepatic Abcb4 and Cyp3a65 mRNA levels and MDR/MXR functional activity was attenuated by co-treatment with PCN and the mammalian PXR antagonist, ketoconazole (KTC). Pregnenolone Carbonitrile 194-197 nuclear receptor subfamily 1 group I member 2 Homo sapiens 52-55 24121122-8 2013 In COS-7 cells co-transfected with a PXR-responsive reporter gene, the full-length Pxr*1 (the more common variant) was activated by known PXR agonists clotrimazole and pregnenolone 16alpha-carbonitrile but to a lesser extent than the full-length human PXR. Pregnenolone Carbonitrile 168-201 nuclear receptor subfamily 1 group I member 2 Homo sapiens 138-141 15367577-3 2005 Pregnenolone 16alpha-carbonitrile (PCN), a glucocorticoid antagonist, efficaciously activates rodent but not human PXR. Pregnenolone Carbonitrile 0-33 nuclear receptor subfamily 1 group I member 2 Homo sapiens 115-118 17093002-5 2007 Treatment of PXR-humanized mice with the PXR ligands mimicked the human response, since both hepatic and intestinal CYP3As were strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16alpha-carbonitrile, a rodent-specific PXR ligand. Pregnenolone Carbonitrile 200-233 nuclear receptor subfamily 1 group I member 2 Homo sapiens 41-44 17093002-5 2007 Treatment of PXR-humanized mice with the PXR ligands mimicked the human response, since both hepatic and intestinal CYP3As were strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16alpha-carbonitrile, a rodent-specific PXR ligand. Pregnenolone Carbonitrile 200-233 nuclear receptor subfamily 1 group I member 2 Homo sapiens 41-44 15367577-3 2005 Pregnenolone 16alpha-carbonitrile (PCN), a glucocorticoid antagonist, efficaciously activates rodent but not human PXR. Pregnenolone Carbonitrile 35-38 nuclear receptor subfamily 1 group I member 2 Homo sapiens 115-118 15322232-4 2004 Moreover, exposing isolated capillaries to the PXR ligands pregnenolone-16alpha-carbonitrile (PCN) and dexamethasone increased p-glycoprotein expression and p-glycoprotein-specific transport of a fluorescent cyclosporine A derivative into capillary lumens. Pregnenolone Carbonitrile 59-92 nuclear receptor subfamily 1 group I member 2 Homo sapiens 47-50 15319343-7 2004 Intriguingly, rifampin and SJW, both activators of the human pregnane X receptor (PXR), induced CYP3A in both liver and intestine but induced P-gp only in intestine, whereas PCN, an activator of murine PXR, did not induce P-gp in any tissue. Pregnenolone Carbonitrile 174-177 nuclear receptor subfamily 1 group I member 2 Homo sapiens 61-80 15319343-7 2004 Intriguingly, rifampin and SJW, both activators of the human pregnane X receptor (PXR), induced CYP3A in both liver and intestine but induced P-gp only in intestine, whereas PCN, an activator of murine PXR, did not induce P-gp in any tissue. Pregnenolone Carbonitrile 174-177 nuclear receptor subfamily 1 group I member 2 Homo sapiens 82-85 15322232-4 2004 Moreover, exposing isolated capillaries to the PXR ligands pregnenolone-16alpha-carbonitrile (PCN) and dexamethasone increased p-glycoprotein expression and p-glycoprotein-specific transport of a fluorescent cyclosporine A derivative into capillary lumens. Pregnenolone Carbonitrile 94-97 nuclear receptor subfamily 1 group I member 2 Homo sapiens 47-50 15180307-8 2004 Taken together, these results indicated that the inhibition of histone deacetylation was required to SXR-mediated increase in CYP3A4 proximal promoter region when rifampicin, or PCN was treated. Pregnenolone Carbonitrile 178-181 nuclear receptor subfamily 1 group I member 2 Homo sapiens 101-104