PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11812922-5 2002 Whereas PCN, 3MC, and PCB all increase microsomal UGT activity toward T(4), only PCN causes an increase in T(3)-UGT activity in vitro. Pregnenolone Carbonitrile 8-11 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 50-53 20421340-9 2010 Compared with the other MEI, only PCN treatment significantly increased T(3) glucuronidation (281 and 497%) in both SD and UGT2B2-deficient F344 rats, respectively, and increased both serum TSH and thyroid follicular cell proliferation. Pregnenolone Carbonitrile 34-37 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 123-129 20421340-10 2010 These data demonstrate an association among increases in T(3) glucuronidation, TSH, and follicular cell proliferation after PCN treatment, suggesting that T(3) is glucuronidated by other PCN-inducible UGTs in addition to UGT2B2. Pregnenolone Carbonitrile 187-190 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 221-227 11812922-5 2002 Whereas PCN, 3MC, and PCB all increase microsomal UGT activity toward T(4), only PCN causes an increase in T(3)-UGT activity in vitro. Pregnenolone Carbonitrile 81-84 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 112-115 10788562-8 2000 T(4) UDP-GT activity was increased in rats treated with PB (120%), PCN (250 to 400%), 3MC (400 to 600%), or PCB (300 to 430%). Pregnenolone Carbonitrile 67-70 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 5-11 10788562-9 2000 In contrast, T(3) UDP-GT activity was increased in rats treated with PB (90%) or PCN (120 to 200%), whereas 3MC and PCB treatments did not have an appreciable effect. Pregnenolone Carbonitrile 81-84 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 18-24 1553754-6 1992 UDP-GT activity toward T4 was increased by PB, 3MC, PCN, and PCB 270, 400, 570, and 660%, respectively, and was found to correlate with serum T4 levels (total and free). Pregnenolone Carbonitrile 52-55 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 0-6 7752103-4 1995 All the UDP-GT inducers produced a dose-dependent induction of hepatic UDP-GT activity toward T4; the increases produced by PCN (7-fold) and PCB (5-fold) were more pronounced than those produced by PB and 3MC (3-fold). Pregnenolone Carbonitrile 124-127 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 8-14 7752103-4 1995 All the UDP-GT inducers produced a dose-dependent induction of hepatic UDP-GT activity toward T4; the increases produced by PCN (7-fold) and PCB (5-fold) were more pronounced than those produced by PB and 3MC (3-fold). Pregnenolone Carbonitrile 124-127 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 71-77 1641859-7 1992 T4 UDP-GT activity was increased by PB, 3MC, PCN, and CLO 88, 150, 100, and 160%, respectively on a per-milligram-microsomal-protein basis and 138, 125, 100, and 145% on a per-kilogram-body-weight basis, respectively. Pregnenolone Carbonitrile 45-48 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 3-9 3120728-0 1987 Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase. Pregnenolone Carbonitrile 15-49 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 110-137 6130905-0 1982 Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16 alpha-carbonitrile. Pregnenolone Carbonitrile 100-134 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 13-40 6130905-1 1982 The effect of pregnenolone-16 alpha-carbonitrile (PCN) on UDP-glucuronosyltransferase (UDP-GT) activity was comprehensively examined in Wistar (JJ), heterozygous (Jj) and Gunn (jj) rats with eleven different acceptors for glucuronic acid. Pregnenolone Carbonitrile 14-48 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 58-85 6130905-1 1982 The effect of pregnenolone-16 alpha-carbonitrile (PCN) on UDP-glucuronosyltransferase (UDP-GT) activity was comprehensively examined in Wistar (JJ), heterozygous (Jj) and Gunn (jj) rats with eleven different acceptors for glucuronic acid. Pregnenolone Carbonitrile 14-48 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 87-93 6130905-1 1982 The effect of pregnenolone-16 alpha-carbonitrile (PCN) on UDP-glucuronosyltransferase (UDP-GT) activity was comprehensively examined in Wistar (JJ), heterozygous (Jj) and Gunn (jj) rats with eleven different acceptors for glucuronic acid. Pregnenolone Carbonitrile 50-53 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 58-85 6130905-1 1982 The effect of pregnenolone-16 alpha-carbonitrile (PCN) on UDP-glucuronosyltransferase (UDP-GT) activity was comprehensively examined in Wistar (JJ), heterozygous (Jj) and Gunn (jj) rats with eleven different acceptors for glucuronic acid. Pregnenolone Carbonitrile 50-53 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 87-93 6130905-12 1982 Thus, 3-MC, PB, and PCN induce UDP-GT activities toward different groups of acceptors of glucuronic acid. Pregnenolone Carbonitrile 20-23 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 31-37 6130905-13 1982 The results support the hypothesis that PCN induces a form of UDP-GT that preferentially conjugates the group-3 acceptors, bilirubin and DIG. Pregnenolone Carbonitrile 40-43 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 62-68 3098175-1 1986 The aim of the present study was to investigate whether the mechanism by which pregnenolone-16 alpha-carbonitrile (PCN) protects rats from digitoxin toxicity was dependent on the induction of liver microsomal cytochrome P-450p and/or the UDP-glucuronosyltransferase active toward digitoxigenin monodigitoxoside (UDP-GT-dt1). Pregnenolone Carbonitrile 79-113 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 238-265 3098175-1 1986 The aim of the present study was to investigate whether the mechanism by which pregnenolone-16 alpha-carbonitrile (PCN) protects rats from digitoxin toxicity was dependent on the induction of liver microsomal cytochrome P-450p and/or the UDP-glucuronosyltransferase active toward digitoxigenin monodigitoxoside (UDP-GT-dt1). Pregnenolone Carbonitrile 115-118 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 238-265