PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33678162-6 2021 CONCLUSION: Our findings indicate that pathogenic E. coli HPI infection of Saba pigs causes pyroptosis of macrophages characterized by upregulated expression of pyroptosis key factors in the NLRP3/ASC/caspase-1 signaling pathway, direct cell membrane pore formation, and secretion of the inflammatory factor IL-1beta and IL-18 downstream of NLRP3 and caspase-1 activation to enhance the inflammatory response. 3-(2-(4-azidobenzamidino)ethyl)-5-hydroxyindole 75-79 interleukin 1 alpha Sus scrofa 308-316