PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32354273-8	2020	No differences in insulin secretion were found between wild type and NOX2 KO islets treated with GW9508 or linoleic acid.Discussion: We report for the first time that acute activation of GPR40 leads to NADPH oxidase activation in pancreatic beta-cells, without impact on insulin secretion.	GW9508	97-103	free fatty acid receptor 1	Rattus norvegicus	187-192	
34275493-6	2021	GPR40 agonist, GW9508, was administered intranasally 1 h, 25 h, and 49 h after GMH induction.	GW9508	15-21	free fatty acid receptor 1	Rattus norvegicus	0-5	
34275493-13	2021	The mechanism study demonstrated that the knockdown of GPR40, PAK4, and KDM6B reversed the neuroprotective effects brought on by GW9508.	GW9508	129-135	free fatty acid receptor 1	Rattus norvegicus	55-60	
31498851-0	2019	G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Calpha and epsilon in INS-1 cells.	GW9508	38-44	free fatty acid receptor 1	Rattus norvegicus	0-29	
31498851-2	2019	We examined whether a GPR40 agonist, GW9508, could stimulate conventional and novel isoforms of PKC at two glucose concentrations (3 mM and 20 mM) in INS-1D cells.	GW9508	37-43	free fatty acid receptor 1	Rattus norvegicus	22-27	
30981281-7	2019	Intrathecal injection of the GPR40 agonist GW9508 dose-dependently attenuated mechanical allodynia and thermal hyperalgesia in neuropathic rats, with Emax values of 80% and 100% MPE and ED50 values of 6.7 and 5.4 mug, respectively.	GW9508	43-49	free fatty acid receptor 1	Rattus norvegicus	29-34	
31295865-5	2019	In vitro, pretreatment of rat proximal tubular (NRK52E) cells with GW9508, a GPR40 agonist, attenuated the decreased cell viability, increased the Bax/Bcl-2 protein expression ratio, increased protein expression of cleaved caspase-3 and activated the nuclear translocation of nuclear factor-kappaB (NF-kappaB) p65 subunit induced by TNF-alpha treatment.	GW9508	67-73	free fatty acid receptor 1	Rattus norvegicus	77-82	
28731171-6	2017	In addition, PTF enhanced the protein expression of GPR40 and to a certain extent strengthened the protein expression of PKC, increased cellular levels of triphosphoinositide (IP3) and diacylglycerol (DAG), and promoted GW9508-stimulated activity of PLC and PKC reduced by PA in INS-1 cells, which were blocked by PLC inhibitor U-73122 and PKC inhibitor staurosporine, respectively.	GW9508	220-226	free fatty acid receptor 1	Rattus norvegicus	52-57	
23628491-1	2013	GW9508 is an agonist of G protein-coupled receptor 40 (GPR40) that is expressed in pancreatic beta-cells and is reported to regulate insulin secretion.	GW9508	0-6	free fatty acid receptor 1	Rattus norvegicus	24-53	
24760994-7	2014	GW9508 (40 muM), an agonist of the FA receptor, G protein-coupled receptor 40 (GPR40), also increased calcium levels almost exclusively in FA-responsive neurons.	GW9508	0-6	free fatty acid receptor 1	Rattus norvegicus	48-77	
24760994-7	2014	GW9508 (40 muM), an agonist of the FA receptor, G protein-coupled receptor 40 (GPR40), also increased calcium levels almost exclusively in FA-responsive neurons.	GW9508	0-6	free fatty acid receptor 1	Rattus norvegicus	79-84	
23628491-1	2013	GW9508 is an agonist of G protein-coupled receptor 40 (GPR40) that is expressed in pancreatic beta-cells and is reported to regulate insulin secretion.	GW9508	0-6	free fatty acid receptor 1	Rattus norvegicus	55-60	
19815053-3	2010	GW9508, a specific agonist of GPR40, significantly enhanced insulin secretion in the presence of high concentrations of glucose.	GW9508	0-6	free fatty acid receptor 1	Rattus norvegicus	30-35