PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22137657-7 2012 injection of DHA (25 and 50mug/mouse) and GW9508 (a GPR40- and GPR120-selective agonist; 0.1 and 1.0mug/mouse) significantly reduced formalin-induced pain behavior. GW9508 42-48 free fatty acid receptor 4 Mus musculus 63-69 28446241-11 2017 Reducing GPR120 hypothalamic expression using a lentivirus-based approach resulted in the loss of the anti-inflammatory effect of GW9508 and increased energy efficiency. GW9508 130-136 free fatty acid receptor 4 Mus musculus 9-15 28446241-12 2017 Intracerebroventricular treatment with the GPR120- and GPR40-specific agonists TUG1197 and TUG905, respectively, resulted in milder effects than those produced by GW9508. GW9508 163-169 free fatty acid receptor 4 Mus musculus 43-49 27489163-7 2016 Treatment of Ffar4 agonist (GW9508) recapitulated the thermogenic activation of EPA by increasing oxygen consumption rate, brown-specific marker genes, and miR-30b and 378, which were abrogated in Ffar4-silenced cells. GW9508 28-34 free fatty acid receptor 4 Mus musculus 13-18 27489163-7 2016 Treatment of Ffar4 agonist (GW9508) recapitulated the thermogenic activation of EPA by increasing oxygen consumption rate, brown-specific marker genes, and miR-30b and 378, which were abrogated in Ffar4-silenced cells. GW9508 28-34 free fatty acid receptor 4 Mus musculus 197-202 24673159-3 2014 We report here that DHA and the GPR120 agonist, GW9508, activate cPLA2 and cyclooxygenase 2 (COX-2), and cause prostaglandin E2 (PGE2) release in a murine macrophage cell line RAW264.7 and in human primary monocyte-derived macrophages. GW9508 48-54 free fatty acid receptor 4 Mus musculus 32-38 16702987-3 2006 Here, we present the first description of GW9508, a small-molecule agonist of the fatty acid receptors GPR40 and GPR120. GW9508 42-48 free fatty acid receptor 4 Mus musculus 113-119 31129318-3 2019 METHODS: The present study investigates the influence of prolonged treatment with GW9508 - agonist of FFAR1 and FFAR4 - on the development of atherosclerosis plaque in apoE-knockout mice, using morphometric and molecular methods. GW9508 82-88 free fatty acid receptor 4 Mus musculus 112-117 31129318-6 2019 CONCLUSIONS: Prolonged administration of GW9508 resulted in significant amelioration of atherogenesis, providing evidence that the strategy based on macrophage phenotype switching toward an M2-like activation state via stimulation of FFAR1/FFAR4 receptors holds promise for a new approach to the prevention or treatment of atherosclerosis. GW9508 41-47 free fatty acid receptor 4 Mus musculus 240-245 26853521-1 2016 Here, we assessed the effects of long-chain fatty acids (LCFAs) and the LCFA receptor agonist GW9508 on the transcription of the gonadotropin subunit genes Cga, Lhb and Fshb because LCFA receptor GPR120 was observed in mouse gonadotropes in our recent study. GW9508 94-100 free fatty acid receptor 4 Mus musculus 196-202 24673159-4 2014 DHA and GW9508 activate cPLA2 via GPR120 receptor, G protein Galphaq and scaffold protein beta-arrestin 2. GW9508 8-14 free fatty acid receptor 4 Mus musculus 34-40 24222669-5 2014 Addition of GW-9508 (a GPR120 chemical agonist) and alpha-linolenic acid (a natural ligand for GPR120) inhibited the secretion of ghrelin by ~50 and 70%, respectively. GW9508 12-19 free fatty acid receptor 4 Mus musculus 23-29 24222669-8 2014 Moreover, we observed that the inhibitory effect of GW-9508 on ghrelin secretion was blocked by a small interfering RNA (siRNA) targeting the sequence of GPR120. GW9508 52-59 free fatty acid receptor 4 Mus musculus 154-160