PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30506812-3	2019	The aim of this study was to investigate effects of mPGES-1 inhibitors, aminothiazoles TH-848 and TH-644, on PGE2 production and osteoclastogenesis in co-cultures of periodontal ligament (PDL) and osteoclast progenitor cells RAW 264.7, stimulated by lipopolysaccharide (LPS), and bone resorption in RANKL-mediated peripheral blood mononuclear cells (PBMCs).	2-aminothiazole	72-86	prostaglandin E synthase	Mus musculus	52-59	
25037914-0	2014	Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARalpha/gamma activation and dual 5-LO/mPGES-1 inhibition.	2-aminothiazole	55-70	prostaglandin E synthase	Mus musculus	133-140	
26987561-2	2016	The aim of this study was to investigate the effect of aminothiazoles targeting prostaglandin E synthase-1 (mPGES-1) on RANKL- and lipopolysaccharide (LPS)-mediated osteoclastogenesis and prostaglandin E2 (PGE2 ) production in vitro using the osteoclast precursor RAW 264.7 cells.	2-aminothiazole	55-69	prostaglandin E synthase	Mus musculus	108-115	
25037914-3	2014	We have recently identified aminothiazole-featured pirinixic acids as dual 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.	2-aminothiazole	28-41	prostaglandin E synthase	Mus musculus	141-148	
25037914-4	2014	Here we present the structure-activity relationship of these aminothiazole-featured pirinixic acids as dual PPARalpha/gamma agonists and discuss their advantages with their potential as dual 5-LO/mPGES-1 inhibitors in inflammatory and cancer diseases.	2-aminothiazole	61-74	prostaglandin E synthase	Mus musculus	196-203	
23447581-6	2013	In summary, these results demonstrate that the aminothiazoles represent novel mPGES-1 inhibitors for inhibition of PGE2 production and reduction of bone resorption in experimental periodontitis, and may be used as potential anti-inflammatory drugs for treatment of chronic inflammatory diseases, including periodontitis.	2-aminothiazole	47-61	prostaglandin E synthase	Mus musculus	78-85	
24171493-6	2013	Together, 2-aminothiazole-featured pirinixic acids represent potent dual 5-LO/mPGES-1 inhibitors with an attractive pharmacological profile as anti-inflammatory drugs.	2-aminothiazole	10-25	prostaglandin E synthase	Mus musculus	78-85