PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33012006-1	2021	We have investigated interactions of galeterone and its pharmacologically active metabolite - 3-keto-Delta4-galeterone (D4G) - with one of the key enzymes of corticosteroid biosynthesis - steroid 21-monooxygenase (CYP21A2).	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	37-47	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	188-212	
33012006-0	2021	Interactions of galeterone and its 3-keto-Delta4 metabolite (D4G) with one of the key enzymes of corticosteroid biosynthesis - steroid 21-monooxygenase (CYP21A2).	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	16-26	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	127-151	
33012006-0	2021	Interactions of galeterone and its 3-keto-Delta4 metabolite (D4G) with one of the key enzymes of corticosteroid biosynthesis - steroid 21-monooxygenase (CYP21A2).	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	16-26	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	153-160	
33012006-1	2021	We have investigated interactions of galeterone and its pharmacologically active metabolite - 3-keto-Delta4-galeterone (D4G) - with one of the key enzymes of corticosteroid biosynthesis - steroid 21-monooxygenase (CYP21A2).	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	37-47	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	214-221	
33012006-3	2021	Spectral dissociation constants (Ks ) of complexes of CYP21A2 with galeterone or D4G were calculated as 3.1 +- 0.7 muM and 4.6 +- 0.4 muM respectively.	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	67-77	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	54-61	
33012006-5	2021	We have revealed using reconstituted monooxygenase system that galeterone is a competitive inhibitor of CYP21A2 with the inhibition constant (Ki ) value of 12 +- 3 muM, while D4G at the concentrations of 10 muM and 25 muM does not inhibit the enzyme.	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	63-73	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	104-111	
33012006-6	2021	Summarizing, based on the in vitro analyses we detected inhibition of CYP21A2 by galeterone and lack of the influence of D4G on this enzyme.	3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene	81-91	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	70-77